Results 121 to 130 of about 26,217 (212)
HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis
Journal of Biological Chemistry, 2018 Viruses exploit the host cell machinery for their own profit. To evade innate immune sensing and promote viral replication, HIV type 1 (HIV-1) subverts DNA repair regulatory proteins and induces G2/M arrest.
Delowar Hossain +3 more
semanticscholar +1 more source
Development and characterization of ten monoclonal anti-Vpr antibodies.
, 2006 International audienceHIV-1 Vpr is a 96-amino acid auxiliary protein that performs numerous activities during viral infection. In the present study, 10 antibodies were generated after mice immunization with either the N- or the C-terminus domain of Vpr ...
Delaunay, Thierry +9 more
core +1 more source
Evidence for Vpr-dependent HIV-1 Replication in Human CD4+ CEM.NKR T-Cells
Retrovirology, 2012 Background Vpr is exclusively expressed in primate lentiviruses and contributes to viral replication and disease progression in vivo. HIV-1 Vpr has two major activities in vitro: arrest of cell cycle in the G2 phase (G2 arrest), and enhancement of viral ...
Zhou Tao +4 more
doaj +1 more source
mBio, 2018 HIV-1 polymerase reverse transcribes the viral RNA genome into imperfectly double-stranded proviral DNA, containing gaps and flaps, for integration into the host cell chromosome.
Jun-Peng Yan +9 more
semanticscholar +1 more source
HIV-1 Accessory Protein Vpr Interacts with REAF/RPRD2 To Mitigate Its Antiviral Activity
Journal of Virology, 2018 For at least 30 years, it has been known that HIV-1 Vpr, a protein carried in the virion, is important for efficient infection of primary macrophages. Vpr is also a determinant of the pathogenic effects of HIV-1 in vivo.
J. Gibbons +12 more
semanticscholar +1 more source
, 2013 A, Confocal immunofluorescent microscopy localized Vpr at the ER. ER was labeled using plasmid encoding ER-targeted Discosoma red fluorescent protein (DsRed-ER). Yellow fluorescence indicates the overlapped regions between Vpr and ER (white arrow).
Shiow-Her Chiou (329314) +4 more
core +1 more source
HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells.
Cell Reports, 2016 Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions.
J. Vermeíre +13 more
semanticscholar +1 more source
PLoS Pathogens, 2013 The precise role of viral protein R (Vpr), an HIV-1-encoded protein, during HIV-1 infection and its contribution to the development of AIDS remain unclear.
Kei Sato +9 more
doaj +1 more source
Mutagenesis and functional studies of the HIV-1 vpr gene and Vpr protein obtained from South African virus strains [PDF]
, 2011 Thesis (PhD)--University of Stellenbosch, 2011.ENGLISH ABSTRACT: Background: Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is an accessory protein that interacts with a number of host cellular and other viral proteins.
Romani, Bizhan
core
HIV-1 LTR activation potential of natural variants of Vpr.
, 2013 HEK-293 T cells were transfected with HIV-1 subtype B LTR or C LTR luciferase reporter plasmid (50 ng), renilla luciferase as normalization control and B Vpr, C Vpr & variant Vpr expression plasmids (100 ng) alone or in combination with B Tat using ...
Vishnampettai G. Ramachandran (499654) +6 more
core +1 more source