Results 101 to 110 of about 26,217 (212)

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Delivery of an Artificial Transcription Regulator dCas9-VPR by Extracellular Vesicles for Therapeutic Gene Activation.

ACS Synthetic Biology, 2018
The CRISPR/Cas system has been developed as a potent tool for genome engineering and transcription regulation. However, the efficiency of the delivery of the system into cells, particularly for therapeutic in vivo applications, remains a major bottleneck.
D. Lainšček, Lucija Kadunc, M. Keber, Iva Hafner Bratkovič, R. Romih, R. Jerala   +5 more
semanticscholar   +1 more source

Inverse detection frequencies of circulating Vpr and anti-Vpr IgG in HIV patients with tumors.

(A) Incidence of Vpr and distribution of Vpr concentrations in HIV patients. Left panel, stacked bar chart showing the proportion of Vpr-positive samples in the matched tumor group (T) and the matched non-tumor group (NT).
Akihiro Matsunaga (3449834), Mari Shimura (31253), Yuko Yamagata (17406799), Hiroyuki Gatanaga (205448), Yukihito Ishizaka (31254), Naokatsu Ando (17721054), Shinichi Oka (205454)   +6 more
core   +1 more source

Characterisation of Lentiviral Vpr Function and Mechanism [PDF]

, 2017
Genetic conflict between viruses and their hosts has driven an ‘arms race’, forcing the evolution of both immune defencesdefenses and multiple viral strategies to counteract and evade them.
Van Tulleken, CR
core   +1 more source

Determining the utility of radio frequency identification (RFID) technology for disaster victim identification (DVI)

Journal of Forensic Sciences, Volume 71, Issue 5, Page 2268-2285, September 2026.
Abstract Radio frequency identification (RFID) technology was evaluated as a method for electronically tracking human remains and associated identifying information during mass fatality incidents. Conventional tags are prone to physical damage and failure, which can compromise identification processes and hinder the repatriation of bodies.
Makena P. McLean, Vienna C. Lam, Megan Bassendale, Gail S. Anderson   +3 more
wiley   +1 more source

The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention

International Journal of Molecular Sciences, 2017
The human immunodeficiency virus type 1 (HIV-1) Vpr protein is an attractive target for antiretroviral drug development. The conservation both of the structure along virus evolution and the amino acid sequence in viral isolates from patients underlines ...
María Eugenia González
semanticscholar   +1 more source

Hydrophobic residues on Vpr helix-1 are important for virion-delivered Vpr cell cycle arrest.

, 2013
WT or mutant Vpr proteins (denoted by the single letter amino acid changes) were delivered (Vprv) into Jurkat cells. Virions containing WT Vpr were titrated (md, medium) so that a matched Vpr protein control could be compared to the mutants.
Diane L. Bolton (344053), Benjamin Chaigne-Delalande (216753), R. Anthony Barnitz (344051), Michael J. Lenardo (255573)   +3 more
core   +1 more source

Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]

, 2009
Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Kaiser, Julia, Schüle Silke, Wolfrum, Nina, Heidmeier Sabine, Sylvia Panitz, Julia K Kaiser, Panitz Sylvia, Klaus Cichutek, Silke Schüle, Heidmeier, Sabine, Kaiser Julia K., Schweizer, Matthias, Cichutek Klaus, Schüle, Silke, Kloke, Björn-Philipp, Matthias Schweizer, Wolfrum Nina, Panitz, Sylvia, Sabine Heidmeier, Cichutek, Klaus, Nina Wolfrum, Kloke Björn-Philipp, Schweizer Matthias, Björn-Philipp Kloke   +23 more
core   +2 more sources

Biogenic Silver Nanoparticles Mediated by Phytoconstituents of the Edible Spice Pimpinella anisum: Characterization and In Vitro, In Vivo, and In Silico Biological Evaluation

Journal of Food Science, Volume 91, Issue 9, September 2026.
ABSTRACT This study evaluated the aqueous extract of Pimpinella anisum seeds (AE‐PAS) and its green‐synthesized silver nanoparticles (PA‐AgNPs) using integrated in vitro, in vivo, and in silico approaches. LC–MS analysis identified 26 phytoconstituents, mainly sinapic acid (15.78%), hispidulin (15.35%), caffeic acid (11.09%), and rutin (8.86%).
Ibtissam Laib, Anis Ben Ali, Soundes Guedda, Nardjes Guedda, Naglaa A. Abd‐Elkarim, Yousef Benaissa, Nariman Essmat, Elhafnaoui Lanez, Mohamed F. Abouelenein, Ahmed I. Osman, Alaa Mahfouz, Ahmed K. Rashwan   +11 more
wiley   +1 more source