Results 91 to 100 of about 26,217 (212)

HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance An obligatory step in the replication cycle of all retroviruses involves reverse transcription of their RNA genomes into double-stranded DNA for integration into the host cell chromosome. The process of synthesizing double-stranded HIV-1 DNA
Jun-Peng Yan, Ming-chieh Shun, Yi Zhang, C. Hao, J. Skowronski   +4 more
semanticscholar   +1 more source

Autophagy regulation by HIV-1 Vpr [PDF]

, 2016
研究成果の概要（和文）：　HIV-1 Vprのオートファジー制御能を独自に発見していた。本研究により制御にVprの既知結合因子は関与しないこと、Vprにはオートファゴソーム形成を促進する領域とオートリソソーム成熟を阻害する領域が存在すると分かった。また、制御のための因子を同定するとともに制御の分子機序を明らかにした。Vprは同定分子と結合することでオートファジーに必須の因子を活性化していると思われる。別に、Vprはオートファジーの最終過程を阻害する活性を持つ ...
ハカタ, ヨシユキ, 博多, 義之, 宮澤, 正顕, ミヤザワ, マサアキ   +3 more
core   +1 more source

Co‐producing process maps to understand and support improvements in the hospital‐to‐school transition following moderate‐to‐severe acquired brain injury in primary school‐aged children

Journal of Neuropsychology, EarlyView.
Abstract Hospital‐to‐school transition following moderate‐to‐severe acquired brain injury (ABI) is a complex, cross‐sectoral process, requiring timely and coordinated information sharing between health professionals, parents and educators. Despite its importance, families and educators often feel underprepared to support the child's return to school ...
Marnie Drake, Shannon Scratch, Emma Tavender, Rowena Conroy, Taylor Jenkin, Adam Scheinberg, Katherine Lingard‐Smith, Kate Heine, Sarah Knight   +8 more
wiley   +1 more source

Integrative Omics Analysis Reveals a CD206+ Macrophage/Dendritic Cell–CD155–TIGIT+ Regulatory T Cell Axis as a Protective Immune Checkpoint Pathway in Atherosclerosis Progression

Barrier Immunity, Volume 2, Issue 3, Page 131-146, September 2026.
ABSTRACT RNA sequencing (RNA‐seq) analysis revealed transcriptional features indicative of sustained immunosuppression within regulatory T cells (Tregs) isolated from atherosclerotic tissues, highlighting the critical contribution of immune checkpoint (ICP) receptor–ligand interactions to atherosclerosis progression. To comprehensively characterize the
Ying Shao, Fatma Saaoud, Mohammed Ben Issa, Keman Xu, Yifan Lu, Shih‐Yu Hung, Juanjuan Liu, Bo Yuan, Juncheng Wei, Sheng Wu, Sadia Mohsin, Zhengjie Zhou, Beata Kosmider, Laisel Martinez, Roberto Vazquez‐Padron, Hong Wang, Xiaofeng Yang   +16 more
wiley   +1 more source

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes.

Virology, 1995
HIV-1 vpr encodes a 96-amino acid, nuclear protein whose function is not well understood. Unlike the other lentivirus regulatory proteins, Vpr is present in virions at relatively high copy number. In cells, Vpr is localized to the nucleus.
R. Connor, Benjamin K. Chen, Sunny S. Choe, N. Landau   +3 more
semanticscholar   +1 more source

Model for HIV1 Vpr-mediated degradation.

, 2012
In the absence of HIV1 Vpr expression, UNG2 engages DCAF1, is ubiquitinated and thus marked for proteasomal degradation (A). In the presence of HIV1 Vpr, CRL4DCAF1-mediated ubiquitination of UNG2 is increased because Vpr enhances the interaction between ...
Carlos M. C. de Noronha (186967), Michael Nekorchuk (186957), Hamayun J. Sharifi (186961), Laurieann Casey Klockow (186954), Xiaoyun Wen (186951)   +4 more
core   +1 more source

Biología molecular de las proteínas accesorias del Virus de la Inmunodeficiencia Humana tipo 1 (VIH-1)

Salud Uninorte, 2005
El Virus de la Inmunodeficiencia Humana tipo 1 (VIH-1) es un retrovirus complejo que codifica 15 distintas proteínas. Algunas de estas proteínas no son esenciales para la replicación viral.
Guillermo Cervantes Acosta
doaj  

Lantana delicata (Verbenaceae), a New Species From Brazil, and Additional Updates Within the Genus

Feddes Repertorium, Volume 137, Issue 3, September 2026.
ABSTRACT In this study, we present some novelties in Lantana, a taxonomically complex genus of Verbenaceae. These include (1) the description of L. delicata, a new species from Brazil; (2) the lectotypification of the name L. magnibracteata; and (3) the recognition of L. fucata f. albiflora, previously regarded as a synonym of L.
Pedro Henrique Cardoso, Juliana Schaefer, Fátima Regina Gonçalves Salimena, Leonardo Jales Leitão, Marcelo Freire Moro, Tânia Regina dos Santos Silva, Nataly O'Leary   +6 more
wiley   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing

Scientific Reports, 2019
Mammals have evolved many antiviral factors impacting different steps of the viral life cycle. Associated with chromatin-modifying enzymes, the cellular cofactor CTIP2 contributes to HIV-1 gene silencing in latently infected reservoirs that constitute ...
F. Forouzanfar, S. Ali, C. Wallet, M. de Rovere, C. Ducloy, H. El Mekdad, M. El Maassarani, A. Aït-Ammar, J. Van Assche, E. Boutant, F. Daouad, F. Margottin-Goguet, C. Moog, C. V. Van Lint, C. Schwartz, O. Rohr   +15 more
semanticscholar   +1 more source