Results 71 to 80 of about 26,217 (212)
HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase. [PDF]
PLoS Pathogens, 2007 Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but factors directly engaged in this process remain unknown.
Jean-Philippe Belzile +5 more
doaj +1 more source
ELECTROPHORESIS, EarlyView.Lentiviral vector purification using QA CIM monolith anion‐exchange chromatography was optimized via 96‐well and DOE, increasing recovery from 20% to 90%. The process achieved 3.3‐log host cell protein reduction, decreased particle impurities, and showed high binding capacity, supporting large‐scale manufacturing.
Luka Bevc +7 more
wiley +1 more source
Journal of Surgical Oncology, EarlyView.ABSTRACT Background Text‐based pathology reports inadequately communicate complex three‐dimensional (3D) relationships in musculoskeletal oncology, potentially contributing to errors in re‐resection and adjuvant treatment planning. While our prior 7‐case pilot study established technical feasibility, the scalability of this workflow and its utility as ...
Riley S. Gilbertson +11 more
wiley +1 more source
Immunofluorescence assay using Vpr-GFP, HA-Vpr and sdAbs Vpr1A and Vpr2A.
, 2014 Immunofluorescence was performed by cotransfecting Hela cells with a plasmid coding for Vpr-GFP (B) or HA-Vpr (C) and increasing amount of a plasmid coding for a sdAb. Vpr-GFP, HA-Vpr and sdAbs were tracked as described in Fig. 3.
Odile Gayet (667485) +7 more
core +1 more source
Virology Journal, 2010 HIV-1 Vpr, a nonstructural viral protein associated with virus particles, has a positive role in the efficient transport of PIC into the nucleus of non-dividing target cells and enhances virus replication in primary T cells.
Klein-Seetharaman Judith +10 more
doaj +1 more source
The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90. [PDF]
PLoS ONE, 2009 BACKGROUND: A hallmark of AIDS progression is a switch of cytokines from Th1 to Th2 in the plasma of patients. IL-12, a critical Th1 cytokine secreted by antigen presenting cells (APCs) is suppressed by Vpr, implicating it as an important virulence ...
Irina Tcherepanova +8 more
doaj +1 more source
Polymer Engineering &Science, EarlyView.Chitosan dispersions containing biochar derived from vine pruning residue showed increasing shear stress and improved thermal stability with loading. Flow behavior was described by the Bingham plastic model in all cases. These results support the valorization of agricultural waste in functional biopolymer formulations.
Ahmet Eser +3 more
wiley +1 more source
Molecules and Cells, 2018 SUMMARY HIV-1 expresses several accessory proteins to counteract host anti-viral restriction factors to facilitate viral replication and disease progression.
Lei Lv +7 more
semanticscholar +1 more source
Apoptosis induced by Vpr variants.
, 2013 (a) The Hela cells were transfected with 2 µg of each plasmid encoding B Vpr, C Vpr and Vpr variants and cells were harvested after 24 hrs using Trypsin EDTA.
Vishnampettai G. Ramachandran (499654) +6 more
core +1 more source
Smart Molecules, EarlyView.AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin +10 more
wiley +1 more source