Results 71 to 80 of about 16,455 (176)
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.Neue biokompatible Oxytocin‐ und Vasopressin‐Photosonden mit modernsten Photocages. Diese Photosonden sind inaktiv und können mit spezifischen Lichtwellen entschützt werden, was eine Rezeptoraktivierung mit hoher zeitlicher und räumlicher Kontrolle ermöglicht. Abbildung erstellt mit https://BioRender.com ZUSAMMENFASSUNG Das Oxytocin/Vasopressin (OT/VP)
Konstantin Raabe +7 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe +7 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.Exploring the chemical profile and biological property of O. majorana EO. ABSTRACT Diabetes mellitus is a widespread metabolic disorder characterized by impaired glucose regulation. This study investigated the chemical composition and antidiabetic potential of Origanum majorana essential oil (EO) using integrated in vitro, in vivo, and computational ...
Mahmoud Houas +12 more
wiley +1 more source
Identification of the 15FRFG domain in HIV-1 Gag p6 essential for Vpr packaging into the virion
Retrovirology, 2004 The auxiliary regulatory protein Vpr of HIV-1 is packaged in the virion through interaction with the Gag C-terminal p6 domain. Virion packaging of Vpr is critical for Vpr to exert functions in the HIV-1 life cycle.
Zhu Henghu, Jian Heng, Zhao Ling-Jun
doaj +1 more source
MedComm, Volume 7, Issue 5, May 2026.Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang +18 more
wiley +1 more source
Construction of a Prokaryotic Expression Vector harboring Two HIV-1 Accessory Genes
Medical Laboratory Journal, 2021 Background and objectives: HIV-1 Nef and Vpr antigens have been described as suitable candidates for therapeutic HIV vaccine development. The aim of this study was to generate Nef-Vpr fusion gene construct and to clone the construct into pET-23a (+), a ...
Arash Nikyar +3 more
doaj
Illuminating the Role of Vpr in HIV Infection of Myeloid Cells
Frontiers in Immunology, 2019 Vpr is a 14 kDa accessory protein conserved amongst extant primate lentiviruses that is required for virus replication in vivo. Although many functions have been attributed to Vpr, its primary role, and the function under selective pressure in vivo ...
Sarah Beth Nodder, Suryaram Gummuluru
doaj +1 more source
mBio, 2019 HIV-1 Vpr enhances viral replication in human macrophages via multiple mechanisms that are not clearly defined. It does not affect HIV-1 virion production during the first round of infection.
Qi Wang, Lishan Su
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Evidence for Vpr-dependent HIV-1 Replication in Human CD4+ CEM.NKR T-Cells
Retrovirology, 2012 Background Vpr is exclusively expressed in primate lentiviruses and contributes to viral replication and disease progression in vivo. HIV-1 Vpr has two major activities in vitro: arrest of cell cycle in the G2 phase (G2 arrest), and enhancement of viral ...
Zhou Tao +4 more
doaj +1 more source