Vpr gene expression in nephrons of Vpr-Tg mice analyzed by BaseScope.
, 2022 (A) negative control image from the WT mouse kidney section which was hybridized using a Vpr probe. (B) The same Vpr probe was hybridized as (A) Vpr RNA (pink), indicated by arrows in images from Tg mouse kidney tissue sections.
Hewang Lee (13839931) +19 more
core +1 more source
Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest. [PDF]
PLoS ONE, 2014 HIV viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/replication stress signalling pathway through engagement of the DDB1-CUL4A-DCAF1 E3 ubiquitin ligase via a direct binding to the substrate ...
Francine C A Gérard +6 more
doaj +1 more source
Nature Microbiology, 2018 Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate.
Leonid Yurkovetskiy +7 more
semanticscholar +1 more source
HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release.
PLoS ONE, 2016 HIV-1 budding requires interaction between Gag and cellular TSG101 to initiate viral particle assembly and release via the endosomal sorting complexes required for transport (ESCRT) pathway.
Nopporn Chutiwitoonchai +5 more
doaj +1 more source
Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells. [PDF]
PLoS ONE, 2012 The Vpr protein of human immunodeficiency virus type 1 (HIV-1) contributes to viral replication in non-dividing cells, specifically those of the myeloid lineage.
Suresh de Silva +2 more
doaj +1 more source
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response
Retrovirology, 2018 Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the ataxia-telangiectasia and Rad3-related protein (ATR)-mediated DNA damage response (DDR).
Kenta Iijima +2 more
doaj +1 more source
Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication [PDF]
Open Biology, 2017 Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a putative HIV-1 restriction ...
Stephan Hofmann +7 more
doaj +1 more source
Advanced Materials, EarlyView.Environmental Synthesis Radar (ESR) evaluates the environmental impact of (early‐stage) multi‐step chemical syntheses, providing a holistic view by using 18 midpoint impact categories. Unlike conventional life‐cycle assessment (LCA) approaches, ESR reveals three complementary metrics: overall impact Vtotal, environmental hotspots VEF, and critical ...
Laura Plein +8 more
wiley +1 more source
Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R
Retrovirology, 2010 Background Cell cycle G2 arrest induced by HIV-1 Vpr is thought to benefit viral proliferation by providing an optimized cellular environment for viral replication and by skipping host immune responses.
Liang Dong +3 more
doaj +1 more source
Extended Anionic Network in Mixed‐Valent Nitridocobaltates(I/II) LnCo2N2 (Ln = La, Pr, Nd)
Advanced Science, EarlyView.This study presents the high‐pressure synthesis of LnCo2N2 (Ln = La, Pr, Nd) with Co in mixed valent states of +I/+II. The compounds demonstrate the stabilization of a nitridocobaltate with extended anionic Co–N layers where Co is threefold coordinated.
Nina A. M. Prinz +5 more
wiley +1 more source