Results 41 to 50 of about 16,455 (176)

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R

Retrovirology, 2010
Background Cell cycle G2 arrest induced by HIV-1 Vpr is thought to benefit viral proliferation by providing an optimized cellular environment for viral replication and by skipping host immune responses.
Liang Dong, Park Hyeon U, Li Ge, Zhao Richard Y   +3 more
doaj   +1 more source

Intrinsic chiroptical responsivity in self‐powered organic photodiodes for polarization‐tunable optical convolution

InfoMat, EarlyView.
Self‐powered chiral organic photodiodes function as polarization‐sensitive convolutional filters for circularly polarized light‐driven optical convolutional neural networks. This conceptually innovative architecture enables dynamic weight modulation, bias‐free operation, and exceptional noise resilience, boosting feature extraction fidelity from 0.15 ...
Lixuan Liu, Weilong Huang, Feihong Zhu, Yongjie Cai, Xiaolong Li, Yang Yang, Xiao Ma, Zhixiang Wei, Wei Chen, Huipeng Chen   +9 more
wiley   +1 more source

Evidence for a cytopathogenicity determinant in HIV-1 Vpr [PDF]

Proceedings of the National Academy of Sciences, 2002
HIV-1 is cytopathic for CD4+T lymphocytesin vitroand this property of HIV-1 is generally considered to account for some of itsin vivocytopathogenicity. Thus, the extent of lymphocyte depletion correlates with the level of viremia whereas low levels of viral replication are typically associated with stable lymphocyte levels and asymptomatic infection ...
Somasundaran, Mohan, Sharkey, Mark E., Brichacek, Beda, Luzuriaga, Katherine, Emerman, Michael, Sullivan, John L., Stevenson, Mario   +6 more
openaire   +3 more sources

Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination

Journal of Translational Medicine, 2020
Background HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cellular E3 ubiquitin ligases (such ...
Patrick Eldin, Sophie Péron, Anastasia Galashevskaya, Nicolas Denis-Lagache, Michel Cogné, Geir Slupphaug, Laurence Briant   +6 more
doaj   +1 more source

Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell death. [PDF]

PLoS ONE, 2011
The human immunodeficiency virus type 1 (HIV-1) accessory protein viral protein R (Vpr) is a major determinant for virus-induced G2/M cell cycle arrest and cytopathicity.
R Anthony Barnitz, Benjamin Chaigne-Delalande, Diane L Bolton, Michael J Lenardo   +3 more
doaj   +1 more source

Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses.

PLoS Pathogens, 2021
Viruses have evolved means to manipulate the host's ubiquitin-proteasome system, in order to down-regulate antiviral host factors. The Vpx/Vpr family of lentiviral accessory proteins usurp the substrate receptor DCAF1 of host Cullin4-RING ligases (CRL4),
Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis J O'Reilly, Ludwig Sinn, Olga Ruda, Juri Rappsilber, Christian M T Spahn, Thorsten Mielke, Ian A Taylor, David Schwefel   +12 more
doaj   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Anti-Vpr Activity of a Yeast Chaperone Protein [PDF]

Journal of Virology, 2004
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) exerts multiple effects on viral and host cellular activities during viral infection, including nuclear transport of the proviral integration complex, induction of cell cycle G 2 arrest, and cell death.
Zsigmond, Benko, Dong, Liang, Emmanuel, Agbottah, Jason, Hou, Karen, Chiu, Min, Yu, Scott, Innis, Patrick, Reed, William, Kabat, Robert T, Elder, Paola, Di Marzio, Lorena, Taricani, Lee, Ratner, Paul G, Young, Michael, Bukrinsky, Richard Yuqi, Zhao   +15 more
openaire   +2 more sources

Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles

Virology Journal, 2010
HIV-1 Vpr, a nonstructural viral protein associated with virus particles, has a positive role in the efficient transport of PIC into the nucleus of non-dividing target cells and enhances virus replication in primary T cells.
Klein-Seetharaman Judith, Srinivasan Alagarsamy, Yanamala Naveena, Li Yaming, Dempsey Timothy M, Le Thien, Tastan Oznur, Walker Leah A, Venkatachari Narasimhan J, Montelaro Ronald C, Ayyavoo Velpandi   +10 more
doaj   +1 more source