HIV-1 Vpr and HIV-2 Vpr modulate the DNA damage response [PDF]
, 2023 HIV-1 and HIV-2 are two evolutionarily district viruses that encode the accessory protein Vpr. Although many functions have been ascribed to HIV-1 and HIV-2 Vpr, the primary and conserved function of Vpr is unknown.
Sandoval, Carina
core +1 more source
Capturing quantitative zooplankton information in the sea: Performance test of laser optical plankton counter and video plankton recorder in a Calanus finmarchicus dominated summer situation [PDF]
, 2012 We compared two optical plankton counters, the Laser Optical Plankton Counter (LOPC) and the Video Plankton Recorder (VPR) for their abundance estimates of Calanus finmarchicus during an early summer situation (June 2008) in two North Norwegian fjords ...
Kristiansen, Stian A. +4 more
core +1 more source
Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions. [PDF]
PLoS ONE, 2009 Although HIV-1 Vpr displays several functions in vitro, limited information exists concerning their relevance during infection. Here, we characterized Vpr variants isolated from a rapid and a long-term non-progressor (LTNP).
Guillaume Jacquot +10 more
doaj +1 more source
HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP. [PDF]
PLoS ONE, 2013 The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase.
Claire Maudet +7 more
doaj +1 more source
mBio, 2022 Integration site landscapes, clonal dynamics, and latency reversal with or without vpr were compared in HIV-1-infected Jurkat cell populations, and the properties of individual clones were defined.
Edmond Atindaana +7 more
doaj +1 more source
Modulation of GR transcriptional signalling by HIV-1 Vpr insights into regulation by progestins [PDF]
, 2012 Includes bibliographical references.It has been 30 years since HIV was first discovered, yet the molecular mechanisms whereby the virus mediates its pathogenic effects have not yet been completely elucidated.
Grantham, N J
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Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages
eLife, 2020 HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary conservation of Vpr suggests an important yet poorly understood role for macrophages in HIV pathogenesis.
Jay Lubow +11 more
semanticscholar +1 more source
Cell Reports, 2019 Summary HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo.
Edward J. D. Greenwood +5 more
semanticscholar +1 more source
mBio, 2020 The DNA damage response (DDR) is a signaling cascade that safeguards the genome from genotoxic agents, including human pathogens. However, the DDR has also been utilized by many pathogens, such as human immunodeficiency virus (HIV), to enhance infection.
Donna Li +4 more
semanticscholar +1 more source
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
Virology Journal, 2007 HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis.
Argañaraz Enrique R +5 more
doaj +1 more source