PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. [PDF]
PLoS ONE, 2010 BACKGROUND: The hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that
Angélique N Godet +6 more
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Evidence Theory and VPRS model
Electronic Notes in Theoretical Computer Science, 2003 AbstractThe Rough Set Theory (RST) was proposed by Pawlak [4] as a new mathematical approach to deal with uncertain knowledge in expert systems. In 1991 Ziarko [11] proposed the Variable Precision Rough Set Model (VPRSM) as a certain extension of the rough set theory.
Marszał-Paszek, Barbara, Paszek, Piotr
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Yeast perspectives on HIV-1 VPR [PDF]
Frontiers in Bioscience, 2000 Increasing evidence suggests that HIV-1 viral protein R (Vpr) plays an important role in viral pathogenesis, as its functions are being linked to viral activation, suppression of human immune functions and depletion of human CD4 lymphocytes, which are the major clinical manifestation of AIDS.
Y, Zhao, R T, Elder
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HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP. [PDF]
PLoS ONE, 2013 The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase.
Claire Maudet +7 more
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HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137
eLife, 2020 The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1 complex.
Fengwen Zhang, Paul D Bieniasz
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Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions. [PDF]
PLoS ONE, 2009 Although HIV-1 Vpr displays several functions in vitro, limited information exists concerning their relevance during infection. Here, we characterized Vpr variants isolated from a rapid and a long-term non-progressor (LTNP).
Guillaume Jacquot +10 more
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Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest. [PDF]
PLoS ONE, 2014 HIV viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/replication stress signalling pathway through engagement of the DDB1-CUL4A-DCAF1 E3 ubiquitin ligase via a direct binding to the substrate ...
Francine C A Gérard +6 more
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mBio, 2022 Integration site landscapes, clonal dynamics, and latency reversal with or without vpr were compared in HIV-1-infected Jurkat cell populations, and the properties of individual clones were defined.
Edmond Atindaana +7 more
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HIV-1 Accessory Proteins: VpR [PDF]
, 2014 HIV-1 viral protein R (VpR) is a multifunctional protein that plays specific roles at multiple stages of the HIV-1 viral life cycle and affects anti-HIV functions of the immune cells. VpR is required for efficient viral replication in nondividing cells such as macrophages, and it promotes, to some extent, viral replication in the proliferating target ...
Richard Y, Zhao, Michael I, Bukrinsky
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HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
Virology Journal, 2007 HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis.
Argañaraz Enrique R +5 more
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