Results 21 to 30 of about 26,217 (212)

HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule.

PLoS ONE, 2022
HIV-associated nephropathy (HIVAN) impairs functions of both glomeruli and tubules. Attention has been previously focused on the HIVAN glomerulopathy. Tubular injury has drawn increased attention because sodium wasting is common in hospitalized HIV/AIDS ...
Shashi Shrivastav, Hewang Lee, Koji Okamoto, Huiyan Lu, Teruhiko Yoshida, Khun Zaw Latt, Hidefumi Wakashin, James L T Dalgleish, Erik H Koritzinsky, Peng Xu, Laureano D Asico, Joon-Yong Chung, Stephen Hewitt, John J Gildea, Robin A Felder, Pedro A Jose, Avi Z Rosenberg, Mark A Knepper, Tomoshige Kino, Jeffrey B Kopp   +19 more
doaj   +2 more sources

NYU-VPR: Long-Term Visual Place Recognition Benchmark with View Direction and Data Anonymization Influences [PDF]

IEEE/RJS International Conference on Intelligent RObots and Systems, 2021
Visual place recognition (VPR) is critical in not only localization and mapping for autonomous driving vehicles, but also assistive navigation for the visually impaired population.
D. Sheng, Yuxiang Chai, Xinru Li, Chen Feng, Jianzhe Lin, Cláudio T. Silva, J. Rizzo   +6 more
semanticscholar   +1 more source

Event-VPR: End-to-End Weakly Supervised Deep Network Architecture for Visual Place Recognition Using Event-Based Vision Sensor

IEEE Transactions on Instrumentation and Measurement, 2022
Traditional visual place recognition (VPR) methods generally use frame-based cameras, which will easily fail due to rapid illumination changes or fast motion.
Delei Kong, Zheng Fang, Kuanxu Hou, Haojia Li, Junjie Jiang, Sonya A. Coleman, D. Kerr   +6 more
semanticscholar   +1 more source

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

Cell Host and Microbe, 2021
SUMMARY Silencing of nuclear DNA is an essential feature of innate immune responses to invading pathogens. Early in infection, unintegrated lentiviral cDNA accumulates in the nucleus yet remains poorly expressed.
L. Dupont, S. Bloor, J. Williamson, S. M. Cuesta, Raven Shah, Ana Teixeira-Silva, Adi Naamati, Edward J. D. Greenwood, S. Sarafianos, N. Matheson, P. Lehner   +10 more
semanticscholar   +1 more source

Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Nature Communications, 2021
The HIV-1 accessory proteins Vif, Vpu, and Nef can promote infection by overcoming the inhibitory effects of the host cell restriction factors APOBEC3G, Tetherin, and SERINC5, respectively.
Li Zhao, Shumei Wang, Meng-Jiao Xu, Yang He, Xiaowei Zhang, Ying Xiong, Hong Sun, Haibo Ding, Wenqing Geng, H. Shang, Guoxin Liang   +10 more
semanticscholar   +1 more source

HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons

Autophagy, 2021
Despite the promising therapeutic effects of combinatory antiretroviral therapy (cART), 20% to 30% of HIV/AIDS patients living with long term infection still exhibit related cognitive and motor disorders.
M. Santerre, Sterling P. Arjona, Charles N. S. Allen, Shannon E. Callen, S. Buch, B. Sawaya   +5 more
semanticscholar   +1 more source

Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]

PLoS ONE, 2011
Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda, Tomoyuki Murakami, Go Matsuda, Hironobu Murakami, Tamotsu Zako, Mizuo Maeda, Yoko Aida   +6 more
doaj   +1 more source

Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development

Kidney International, 2022
Chronic kidney disease (CKD) is a common cause of morbidity in human immunodeficiency virus (HIV)-positive individuals. HIV infection leads to a wide spectrum of kidney cell damage, including tubular epithelial cell (TEC) injury. Among the HIV-1 proteins,
Yu-Qiang Chen, Ya Chen, Jia Fu, Zeguo Sun, Huilin Li, Wenzhen Xiao, E. Jing, Benjamin Lo, Nian-Song Wang, Weijia Zhang, M. Klotman, P. Klotman, J. Kopp, V. D'Agati, J. He, Kyung Lee   +15 more
semanticscholar   +1 more source

The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover. [PDF]

PLoS ONE, 2012
The HIV1 protein Vpr assembles with and acts through an ubiquitin ligase complex that includes DDB1 and cullin 4 (CRL4) to cause G2 cell cycle arrest and to promote degradation of both uracil DNA glycosylase 2 (UNG2) and single-strand selective mono ...
Xiaoyun Wen, Laurieann Casey Klockow, Michael Nekorchuk, Hamayun J Sharifi, Carlos M C de Noronha   +4 more
doaj   +1 more source

Protein Arginine N-methyltransferases 5 and 7 Promote HIV-1 Production

Viruses, 2020
Current therapies for human immunodeficiency virus type 1 (HIV-1) do not completely eliminate viral reservoirs in cells, such as macrophages. The HIV-1 accessory protein viral protein R (Vpr) promotes virus production in macrophages, and the maintenance ...
Hironobu Murakami, Takehiro Suzuki, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Manabu Taura, Eriko Kudo, Seiji Okada, Masami Takei, Kazumichi Kuroda, Tatsuo Yamamoto, Kyoji Hagiwara, Naoshi Dohmae, Yoko Aida   +12 more
doaj   +1 more source