Results 1 to 10 of about 21,828 (174)
Vpr and Its Cellular Interaction Partners: R We There Yet?
Cells, 2019 Vpr is a lentiviral accessory protein that is expressed late during the infection cycle and is packaged in significant quantities into virus particles through a specific interaction with the P6 domain of the viral Gag precursor.
Helena Fábryová, Klaus Strebel
exaly +4 more sources
HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7
Virology Journal, 2021 Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou +3 more
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HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrest
mBioLentiviruses encode a number of multi-functional accessory proteins, however, the primary role of the accessory protein Vpr remains unclear. As Vpr engages the host DNA damage response (DDR) at multiple steps, modulation of the DDR is considered central ...
Carina Sandoval +2 more
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HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137
eLife, 2020 The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1 complex.
Fengwen Zhang, Paul D Bieniasz
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New Insights Into the Virus-to-Prokaryote Ratio (VPR) in Marine Sediments
Frontiers in Microbiology, 2020 The virus-to-prokaryote ratio (VPR), which reflects the numerical dominance of viruses over their hosts, has been proposed as a proxy for assessing the relationship between viruses and prokaryotes.
Miao Wei +5 more
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PLoS Pathogens, 2021 Viruses have evolved means to manipulate the host's ubiquitin-proteasome system, in order to down-regulate antiviral host factors. The Vpx/Vpr family of lentiviral accessory proteins usurp the substrate receptor DCAF1 of host Cullin4-RING ligases (CRL4),
Sofia Banchenko +12 more
doaj +2 more sources
Evolution of a concept: From accessory protein to key virulence factor, the case of HIV-1 Vpr
Biochemical Pharmacology, 2020 Back in 1989 some studies have shown that the viral protein Vpr was dispensable for HIV-1 replication in vitro. From then the concept of accessory or auxiliary protein for Vpr has emerged and it is still used to date.
Olivier Rohr, Christian Schwartz
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Vpr Is a VIP: HIV Vpr and Infected Macrophages Promote Viral Pathogenesis
Viruses, 2020 HIV infects several cell types in the body, including CD4+ T cells and macrophages. Here we review the role of macrophages in HIV infection and describe complex interactions between viral proteins and host defenses in these cells.
Kathleen Collins, Jay Lubow
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Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A
Nature Communications, 2021 Vpr is a HIV-1 accessory virulence factor that also interacts with the human DNA repair protein hHR23A. Here, the authors present the structure of Vpr in complex with the C-terminal half of hHR23A comprising the XPC-binding and ubiquitin-associated ...
In-Ja L. Byeon +11 more
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HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages
Nature CommunicationsHIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env).
Maria C. Virgilio +6 more
doaj +2 more sources