Results 1 to 10 of about 16,455 (176)
HIV-1 Vpr is targeted for degradation by autophagy. [PDF]
PLoS PathogensAutophagy is part of the innate immune arsenal to fight viruses, including HIV-1. We previously reported that HIV-1 Gag is targeted for autophagy-mediated degradation.
Yuexuan Chen +4 more
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HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells [PDF]
mBioHIV-1 Vpr has a major impact on the cellular transcriptome and proteome. Although Vpr is known to stimulate the nuclear factor of activated T cells (NFAT), it remained unclear to what extent transcriptional changes induced by Vpr are governed by NFAT. We,
Johanna Leyens +7 more
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Vpr and Its Cellular Interaction Partners: R We There Yet?
Cells, 2019 Vpr is a lentiviral accessory protein that is expressed late during the infection cycle and is packaged in significant quantities into virus particles through a specific interaction with the P6 domain of the viral Gag precursor.
Helena Fábryová +2 more
exaly +3 more sources
De Novo Expressed Vpr Stimulates HIV-1 Replication in T Cells [PDF]
VirusesVpr, a virion-associated accessory virulence factor of HIV-1, promotes virus replication in both T cells and macrophages. Although Vpr’s early activity—antagonism of preintegration silencing and host restriction factors—has been documented, the relative ...
Blessing Enya, Jacek Skowronski
doaj +2 more sources
PLoS ONE, 2022 HIV-associated nephropathy (HIVAN) impairs functions of both glomeruli and tubules. Attention has been previously focused on the HIVAN glomerulopathy. Tubular injury has drawn increased attention because sodium wasting is common in hospitalized HIV/AIDS ...
Shashi Shrivastav +19 more
doaj +2 more sources
Protein Arginine N-methyltransferases 5 and 7 Promote HIV-1 Production
Viruses, 2020 Current therapies for human immunodeficiency virus type 1 (HIV-1) do not completely eliminate viral reservoirs in cells, such as macrophages. The HIV-1 accessory protein viral protein R (Vpr) promotes virus production in macrophages, and the maintenance ...
Hironobu Murakami +12 more
doaj +1 more source
Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]
PLoS ONE, 2011 Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda +6 more
doaj +1 more source
Parallel FPGA Routers With Lagrange Relaxation
IEEE Access, 2023 Routing of the nets in Field Programmable Gate Array (FPGA) design flow is one of the most time consuming steps. Although Versatile Place and Route (VPR), which is a commonly used algorithm for this purpose, routes effectively, it is slow in execution ...
Rohit Agrawal +5 more
doaj +1 more source
Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins
Viruses, 2020 Viral protein R (Vpr) is an accessory protein found in various primate lentiviruses, including human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) as well as simian immunodeficiency viruses (SIVs).
Hao Chang +6 more
doaj +1 more source
The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover. [PDF]
PLoS ONE, 2012 The HIV1 protein Vpr assembles with and acts through an ubiquitin ligase complex that includes DDB1 and cullin 4 (CRL4) to cause G2 cell cycle arrest and to promote degradation of both uracil DNA glycosylase 2 (UNG2) and single-strand selective mono ...
Xiaoyun Wen +4 more
doaj +1 more source