Parallel FPGA Routers With Lagrange Relaxation
IEEE Access, 2023 Routing of the nets in Field Programmable Gate Array (FPGA) design flow is one of the most time consuming steps. Although Versatile Place and Route (VPR), which is a commonly used algorithm for this purpose, routes effectively, it is slow in execution ...
Rohit Agrawal +5 more
doaj +1 more source
Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection [PDF]
Open Biology, 2016 The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription.
Kristin Höhne +9 more
doaj +1 more source
ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses
PLoS Pathogens, 2021 Previously, we reported that cellular transcription factor ZASC1 facilitates DNA-dependent/RNA-independent recruitment of HIV-1 TAT and the cellular elongation factor P-TEFb to the HIV-1 promoter and is a critical factor in regulating HIV-1 ...
James W. Bruce +4 more
semanticscholar +1 more source
Vpr-mediated regulation of miR-210-5p expression.
, 2021 (A) Promoter analysis using a series of reporter plasmids involving the miR-210-5p promoter (intact, f1; truncated, f2; mutated, f3) with pCMV-Flag-Vpr in HOS cells.
Lixia Huang (429197) +9 more
core +1 more source
Pair-VPR: Place-Aware Pre-Training and Contrastive Pair Classification for Visual Place Recognition With Vision Transformers [PDF]
IEEE Robotics and Automation LettersIn this work we propose a novel joint training method for Visual Place Recognition (VPR), which simultaneously learns a global descriptor and a pair classifier for re-ranking.
Stephen Hausler, P. Moghadam
semanticscholar +1 more source
A gene therapy for inherited blindness using dCas9-VPR–mediated transcriptional activation
Science Advances, 2020 Inherited blindness can be treated with a safe gene therapy approach using activation of functionally equivalent genes. Catalytically inactive dCas9 fused to transcriptional activators (dCas9-VPR) enables activation of silent genes.
Sybille Böhm +13 more
semanticscholar +1 more source
Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1 [PDF]
, 2013 SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr
Emerman, M +23 more
core +2 more sources
Unexploited Performance of NLS in the dCas9-VPR-Mediated Transcriptional Activation
, 2023 Nuclear localization signal (NLS) is a short peptide guiding the nuclear transport process, recognized as playing an important role in constructing clustered regularly interspaced short palindromic repeats-Cas (CRISPR-Cas) activators.
Miao He (148269) +11 more
core +1 more source
PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. [PDF]
PLoS ONE, 2010 BACKGROUND: The hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that
Angélique N Godet +6 more
doaj +1 more source
bioRxiv, 2020 HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specific ...
Hataf Khan +11 more
semanticscholar +1 more source