Results 31 to 40 of about 16,455 (176)

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrest

mBio
Lentiviruses encode a number of multi-functional accessory proteins, however, the primary role of the accessory protein Vpr remains unclear. As Vpr engages the host DNA damage response (DDR) at multiple steps, modulation of the DDR is considered central ...
Carina Sandoval, Karly Nisson, Oliver I. Fregoso   +2 more
doaj   +1 more source

HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release.

PLoS ONE, 2016
HIV-1 budding requires interaction between Gag and cellular TSG101 to initiate viral particle assembly and release via the endosomal sorting complexes required for transport (ESCRT) pathway.
Nopporn Chutiwitoonchai, Lowela Siarot, Eri Takeda, Tatsuo Shioda, Motoki Ueda, Yoko Aida   +5 more
doaj   +1 more source

HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.

PLoS ONE, 2010
HIV-1 Vpr is a virion-associated protein. Its activities link to viral pathogenesis and disease progression of HIV-infected patients. In vitro, Vpr moderately activates HIV-1 replication in proliferating T cells, but it is required for efficient viral ...
Ge Li, Robert T Elder, Larisa Dubrovsky, Dong Liang, Tatiana Pushkarsky, Karen Chiu, Tao Fan, Josephine Sire, Michael Bukrinsky, Richard Y Zhao   +9 more
doaj   +1 more source

Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells. [PDF]

PLoS ONE, 2012
The Vpr protein of human immunodeficiency virus type 1 (HIV-1) contributes to viral replication in non-dividing cells, specifically those of the myeloid lineage.
Suresh de Silva, Vicente Planelles, Li Wu   +2 more
doaj   +1 more source

Productivity‐Driven Optimization of Laser Powder Bed Fusion Parameters for IN718 Superalloy: Process Control, Microstructure, and Mechanical Properties

Advanced Engineering Materials, EarlyView.
This study demonstrates how optimizing laser power, scanning speed, and hatching distance in laser powder bed fusion can boost the productivity of Inconel 718 manufacturing by up to 29% while maintaining mechanical integrity. The work delivers a validated process window and cost–time analysis, offering industry‐ready guidelines for efficient additive ...
Amir Behjat, Guido Barale, John Stavridis, Ehsan Norouzi, Jin‐Yoo Suh, Dong‐Ik Kim, Luca Iuliano, Abdollah Saboori   +7 more
wiley   +1 more source

HIV-1, Vpr and the cell cycle [PDF]

Current Biology, 1996
The human immunodeficiency virus 1 (HIV-1) is a complex retrovirus with more genes than most retroviruses. One of these extra genes codes for a protein called Vpr, which has recently been shown to prevent activation of the mitotic cyclin-dependent kinase and thereby prevent infected cells from undergoing mitosis and proliferating.
openaire   +2 more sources

Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response

Retrovirology, 2018
Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the ataxia-telangiectasia and Rad3-related protein (ATR)-mediated DNA damage response (DDR).
Kenta Iijima, Junya Kobayashi, Yukihito Ishizaka   +2 more
doaj   +1 more source

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication [PDF]

Open Biology, 2017
Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a putative HIV-1 restriction ...
Stephan Hofmann, Sandra Dehn, Ramona Businger, Sebastian Bolduan, Martha Schneider, Zeger Debyser, Ruth Brack-Werner, Michael Schindler   +7 more
doaj   +1 more source

Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages

Viruses, 2021
Human immunodeficiency virus type 1 (HIV-1) modulates the host cell cycle. The HIV-1 accessory protein Vpr arrests the cell cycle at the G2 phase in dividing cells, and the ability of Vpr to induce G2 arrest is well conserved among primate lentiviruses ...
Tomoyuki Murakami, Ryosuke Matsuura, Nopporn Chutiwitoonchai, Masami Takei, Yoko Aida   +4 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source