Results 11 to 20 of about 16,455 (176)
Retrovirology, 2007 Background HIV-1 Vpr is a dynamic protein that primarily localizes in the nucleus, but a significant fraction is concentrated at the nuclear envelope (NE), supporting an interaction between Vpr and components of the nuclear pore complex, including the ...
Bouaziz Serge +8 more
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Visualizing Vpr-induced G2 arrest and apoptosis. [PDF]
PLoS ONE, 2014 Vpr is an accessory protein of human immunodeficiency virus type 1 (HIV-1) with multiple functions. The induction of G2 arrest by Vpr plays a particularly important role in efficient viral replication because the transcriptional activity of the HIV-1 ...
Tomoyuki Murakami, Yoko Aida
doaj +4 more sources
Vpr Is a VIP: HIV Vpr and Infected Macrophages Promote Viral Pathogenesis [PDF]
Viruses, 2020 HIV infects several cell types in the body, including CD4+ T cells and macrophages. Here we review the role of macrophages in HIV infection and describe complex interactions between viral proteins and host defenses in these cells. Macrophages exist in many forms throughout the body, where they play numerous roles in healthy and diseased states.
Jay Lubow, Kathleen L. Collins
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Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection [PDF]
Open Biology, 2016 The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription.
Kristin Höhne +9 more
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HIV-1 Vpr Oligomerization but Not That of Gag Directs the Interaction between Vpr and Gag [PDF]
Journal of Virology, 2010 ABSTRACT During HIV-1 assembly, the viral protein R (Vpr) is incorporated into newly made viral particles via an interaction with the C-terminal domain of the Gag polyprotein precursor Pr55 Gag .
Joëlle V, Fritz +7 more
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HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7
Virology Journal, 2021 Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou +3 more
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Vipirinin, a Coumarin-based HIV-1 Vpr Inhibitor, Interacts with a Hydrophobic Region of VPR [PDF]
Journal of Biological Chemistry, 2011 La proteína viral R (Vpr) del virus de la inmunodeficiencia humana 1 (VIH-1) es una proteína accesoria que se ha demostrado que tiene múltiples funciones en la patogénesis del VIH-1. Mediante el cribado de bibliotecas químicas en el Depósito de Productos Naturales de RIKEN, identificamos un compuesto a base de 3-fenil cumarina que inhibía la actividad ...
Eugene Boon Beng Ong +7 more
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Inhibition of NF‐κB activity by HIV‐1 Vpr is dependent on Vpr binding protein [PDF]
Journal of Cellular Physiology, 2012 AbstractNumerous studies have reported that Vpr alters NF‐κB signaling in various cell types, however, the findings have been largely conflicting with reports of both stimulatory and inhibitory effects of Vpr. Our aim was to investigate the role of Vpr signaling in myeloid cells using an adenovirus based expression and indicator system.
Michael, Kogan +5 more
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Retrovirology, 2008 Background The human immunodeficiency virus type 1 (HIV-1) encodes several regulatory proteins, notably Vpr which influences the survival of the infected cells by causing a G2/M arrest and apoptosis.
Mély Yves +10 more
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New Insights Into the Virus-to-Prokaryote Ratio (VPR) in Marine Sediments
Frontiers in Microbiology, 2020 The virus-to-prokaryote ratio (VPR), which reflects the numerical dominance of viruses over their hosts, has been proposed as a proxy for assessing the relationship between viruses and prokaryotes.
Miao Wei +5 more
doaj +1 more source