Visualizing Vpr-induced G2 arrest and apoptosis. [PDF]
PLoS ONE, 2014 Vpr is an accessory protein of human immunodeficiency virus type 1 (HIV-1) with multiple functions. The induction of G2 arrest by Vpr plays a particularly important role in efficient viral replication because the transcriptional activity of the HIV-1 ...
Tomoyuki Murakami, Yoko Aida
doaj +2 more sources
Direct Vpr-Vpr Interaction in Cells monitored by two Photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging [PDF]
Retrovirology, 2008 Background The human immunodeficiency virus type 1 (HIV-1) encodes several regulatory proteins, notably Vpr which influences the survival of the infected cells by causing a G2/M arrest and apoptosis.
Mély Yves +10 more
doaj +2 more sources
Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages [PDF]
Retrovirology, 2007 Background HIV-1 Vpr is a dynamic protein that primarily localizes in the nucleus, but a significant fraction is concentrated at the nuclear envelope (NE), supporting an interaction between Vpr and components of the nuclear pore complex, including the ...
Bouaziz Serge +8 more
doaj +2 more sources
Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins
Viruses, 2020 Viral protein R (Vpr) is an accessory protein found in various primate lentiviruses, including human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) as well as simian immunodeficiency viruses (SIVs).
Hao Chang +6 more
doaj +2 more sources
HIV-1 Vpr is targeted for degradation by autophagy. [PDF]
PLoS PathogensAutophagy is part of the innate immune arsenal to fight viruses, including HIV-1. We previously reported that HIV-1 Gag is targeted for autophagy-mediated degradation.
Yuexuan Chen +4 more
doaj +2 more sources
HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells [PDF]
mBioHIV-1 Vpr has a major impact on the cellular transcriptome and proteome. Although Vpr is known to stimulate the nuclear factor of activated T cells (NFAT), it remained unclear to what extent transcriptional changes induced by Vpr are governed by NFAT. We,
Johanna Leyens +7 more
doaj +2 more sources
Illuminating the Role of Vpr in HIV Infection of Myeloid Cells
Frontiers in Immunology, 2019 Vpr is a 14 kDa accessory protein conserved amongst extant primate lentiviruses that is required for virus replication in vivo. Although many functions have been attributed to Vpr, its primary role, and the function under selective pressure in vivo ...
Sarah Beth Nodder, Suryaram Gummuluru
doaj +2 more sources
Scientific Reports, 2017 HIV patients develop hepatic steatosis. We investigated hepatic steatosis in transgenic mice expressing the HIV-1 accessory protein Vpr (Vpr-Tg) in liver and adipose tissues, and WT mice infused with synthetic Vpr.
Neeti Agarwal +11 more
doaj +2 more sources
STA-VPR: Spatio-Temporal Alignment for Visual Place Recognition [PDF]
IEEE Robotics and Automation Letters, 2021 Recently, the methods based on Convolutional Neural Networks (CNNs) have gained popularity in the field of visual place recognition (VPR). In particular, the features from the middle layers of CNNs are more robust to drastic appearance changes than ...
Feng Lu +3 more
semanticscholar +1 more source
VPR-Bench: An Open-Source Visual Place Recognition Evaluation Framework with Quantifiable Viewpoint and Appearance Change [PDF]
International Journal of Computer Vision, 2020 Visual place recognition (VPR) is the process of recognising a previously visited place using visual information, often under varying appearance conditions and viewpoint changes and with computational constraints.
Mubariz Zaffar +6 more
semanticscholar +1 more source