Results 61 to 70 of about 26,217 (212)
HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation [PDF]
, 2004 The auxiliary regulatory protein Vpr of HIV-1 possesses several biological activities which are believed to facilitate HIV-1 replication and pathogenesis.
Jian, Heng +5 more
core +1 more source
HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.
PLoS ONE, 2010 HIV-1 Vpr is a virion-associated protein. Its activities link to viral pathogenesis and disease progression of HIV-infected patients. In vitro, Vpr moderately activates HIV-1 replication in proliferating T cells, but it is required for efficient viral ...
Ge Li +9 more
doaj +1 more source
Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages
Viruses, 2021 Human immunodeficiency virus type 1 (HIV-1) modulates the host cell cycle. The HIV-1 accessory protein Vpr arrests the cell cycle at the G2 phase in dividing cells, and the ability of Vpr to induce G2 arrest is well conserved among primate lentiviruses ...
Tomoyuki Murakami +4 more
doaj +1 more source
Advanced Science, EarlyView.Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit +10 more
wiley +1 more source
Vpr complementation does not affect Vpr-defective single-cycle HIV-1 infection of MDDCs.
, 2013 (A) Vpr incorporation in VSV-G-pseudotyped, single-cycle HIV-Vpr+ and Vpr-complemented HIV-Vpr-. Virion pellets were analyzed by immunoblotting with anti-Vpr and anti-p24, respectively.
Vicente Planelles (31768) +2 more
core +1 more source
Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell death. [PDF]
PLoS ONE, 2011 The human immunodeficiency virus type 1 (HIV-1) accessory protein viral protein R (Vpr) is a major determinant for virus-induced G2/M cell cycle arrest and cytopathicity.
R Anthony Barnitz +3 more
doaj +1 more source
Interventional therapies for chronic heart failure: An overview of recent developments
ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo +7 more
wiley +1 more source
bioRxiv, 2020 Effective antiretroviral therapies can now prolong patients’ lives to nearly normal life span. The current challenge faced by many HIV-infected patients is chronic neuroinflammation and neurotoxicity that contributes to HIV-associated neurocognitive ...
Ge Li +9 more
semanticscholar +1 more source
, 2013 A, Using Percoll self-generating gradient fractionation, Vpr-GFP was localized in the ER, MAM, and mitochondria. Cyto: cytosolic fraction, LM: microsomal fraction, Mito: mitochondrial fraction.
Shiow-Her Chiou (329314) +4 more
core +1 more source
Journal of Translational Medicine, 2020 Background HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cellular E3 ubiquitin ligases (such ...
Patrick Eldin +6 more
doaj +1 more source