Results 61 to 70 of about 16,455 (176)
Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.Inducible CRISPR/Cas systems enable spatiotemporal genome editing in precision oncology. Chemical, optical, physical, and microenvironmental stimuli provide distinct control strategies. Conditional activation may reduce off‐target exposure and basal nuclease activity.
Ziliang Ding +3 more
wiley +1 more source
Vpr loosens chromatid ties [PDF]
Journal of Cell Biology, 2011 ![Figure][1] Compared to cells lacking Vpr (left), the cohesin Rad21 (red) is prematurely lost from centromeres (arrowheads) in the presence of Vpr (right). An HIV-1 protein promotes chromosome missegregation by epigenetically modifying centromeric chromatin, [Shimura et al.][2] report.
openaire +1 more source
Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest. [PDF]
PLoS Pathogens, 2010 HIV-1 Viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/stress checkpoint. Recently, we and several other groups showed that Vpr performs this activity by recruiting the DDB1-CUL4A (VPRBP) E3 ubiquitin ...
Jean-Philippe Belzile +4 more
doaj +1 more source
ChemistryOpen, Volume 15, Issue 6, June 2026.Fagonia cretica L.: Phytochemical investigation and exploration of bioactivity through in vitro and in silico approaches. This study provides an integrative evaluation of the aqueous extract of Fagonia cretica L., a species long employed in traditional medicine but insufficiently characterized through systematic experimental and computational ...
Neghmouche Nacer Salah +8 more
wiley +1 more source
HIV‐1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation [PDF]
FEBS Letters, 2004 The auxiliary regulatory protein Vpr of HIV‐1 possesses several biological activities which are believed to facilitate HIV‐1 replication and pathogenesis. In this report, experimental evidence suggests a novel biological activity of Vpr: facilitation of the turnover of Vpr mutants bearing the L64P mutation.
Zhao, Ling-Jun, Jian, Heng, Zhu, Henghu
openaire +2 more sources
Salud Uninorte, 2005 El Virus de la Inmunodeficiencia Humana tipo 1 (VIH-1) es un retrovirus complejo que codifica 15 distintas proteínas. Algunas de estas proteínas no son esenciales para la replicación viral.
Guillermo Cervantes Acosta
doaj
On Predicting Vulnerability Severity Using In‐Context Learning: An Industrial Case Study
Journal of Software: Evolution and Process, Volume 38, Issue 6, June 2026.ABSTRACT Modern software systems require earlier and more scalable vulnerability severity assessment to reduce exposure to high‐impact security flaws. Security analysts typically assign CVSS scores, but this manual triage does not scale with the growth of disclosed vulnerabilities and often depends on cloud LLM services that raise confidentiality ...
Daniel Rodriguez‐Cardenas +10 more
wiley +1 more source
Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A
Nature Communications, 2021 Vpr is a HIV-1 accessory virulence factor that also interacts with the human DNA repair protein hHR23A. Here, the authors present the structure of Vpr in complex with the C-terminal half of hHR23A comprising the XPC-binding and ubiquitin-associated ...
In-Ja L. Byeon +11 more
doaj +1 more source
American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias +3 more
wiley +1 more source
Progression to AIDS in the absence of a gene for vpr or vpx [PDF]
Journal of Virology, 1995 Rhesus monkeys (Macaca mulatta) were experimentally infected with strains of simian immunodeficiency virus (SIV) derived from SIVmac239 lacking vpr, vpx, or both vpr and vpx genes. These auxiliary genes are not required for virus replication in cultured cells but are consistently conserved within the SIVmac/human immunodeficiency virus type 2/SIVsm ...
J S, Gibbs +6 more
openaire +2 more sources