Results 111 to 120 of about 26,217 (212)
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti +10 more
wiley +1 more source
Molecular & Cellular Proteomics, 2017 The mechanisms by which human immunodeficiency virus (HIV) circumvents and coopts cellular machinery to replicate and persist in cells are not fully understood.
John D. Lapek +4 more
semanticscholar +1 more source
Identification of the 15FRFG domain in HIV-1 Gag p6 essential for Vpr packaging into the virion
Retrovirology, 2004 The auxiliary regulatory protein Vpr of HIV-1 is packaged in the virion through interaction with the Gag C-terminal p6 domain. Virion packaging of Vpr is critical for Vpr to exert functions in the HIV-1 life cycle.
Zhu Henghu, Jian Heng, Zhao Ling-Jun
doaj +1 more source
HIV-1 Vpr disrupts mitochondria axonal transport and accelerates neuronal aging
Neuropharmacology, 2017 &NA; Disruption of mitochondria axonal transport, essential for the maintenance of synaptic and neuronal integrity and function, has been identified in neurodegenerative diseases.
Ying Wang +5 more
semanticscholar +1 more source
Construction of a Prokaryotic Expression Vector harboring Two HIV-1 Accessory Genes
Medical Laboratory Journal, 2021 Background and objectives: HIV-1 Nef and Vpr antigens have been described as suitable candidates for therapeutic HIV vaccine development. The aim of this study was to generate Nef-Vpr fusion gene construct and to clone the construct into pET-23a (+), a ...
Arash Nikyar +3 more
doaj
HIV-1 Vpr and p21 restrict LINE-1 mobility
Nucleic Acids Research, 2018 Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However, genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain poorly understood.
Koudai Kawano +12 more
semanticscholar +1 more source
hHR23A is critical for Vpr-proteasome interaction.
, 2013 A. In vitro and in vivo interactions of Rhp23 with HIV-1 Vpr. (i) Rhp23, a fission yeast homologue of mammalian hHR23A[15], interacts with Vpr in the yeast two-hybrid system.
Josephine Sire (5653531) +9 more
core +1 more source
The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction
Nature Structural &Molecular Biology, 2016 The HIV-1 accessory protein Vpr is required for efficient viral infection of macrophages and promotion of viral replication in T cells. Vpr's biological activities are closely linked to the interaction with human DCAF1, a cellular substrate receptor of ...
Ying Wu +7 more
semanticscholar +1 more source
Correlation of anti-Vpr IgG level, HIV RNA level and Vpr levels.
(A) Relationship between anti-Vpr IgG level and HIV RNA in 72 HIV viremic patients. The horizontal dotted line is the detection limit of HIV RNA (20 copies/mL), and the vertical dotted line is the detection limit of anti-Vpr IgG (optical density at 450nm;
Akihiro Matsunaga (3449834) +6 more
core +1 more source
Usefulness of Bench-top VPR(B-VPR) in Measuring Formalin-preservedZooplankton Samples [PDF]
, 2009 Zooplankton， especially of the class Copepoda， are an important component of the diets of most fish species during development. Consequently， copepod size and species composition can affect fish larval survival and therefore fisheries resources. However，
Tanaka, Teruki +17 more
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