Mitochondrial Diseases: Molecular Pathogenesis and Therapeutic Advances
MedComm, Volume 6, Issue 9, September 2025.Key pathogenic mechanisms—OXPHOS defects, heteroplasmy, impaired mtDNA repair, disrupted dynamics/mitophagy, and inflammatory signaling—drive multiorgan involvement in mitochondrial diseases. Targeted interventions include metabolic drugs (CoQ10, idebenone, EPI‐743), mitochondrial gene editing (DdCBE, mitoBEs, CyDENT/mitoTALEN/mtZFN), and mitochondrial
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Rearrangement of a Stable RNA Secondary Structure during VS Ribozyme Catalysis [PDF]
, 2000 Angela A. Andersen, Richard A. Collins
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Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from neurospora VS RNA. [PDF]
, 1995 Hwai‐Chen Guo, Richard A. Collins
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Études structurales et ingénierie du ribozyme VS de Neurospora
, 2020 Dagenais, Pierre
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The contribution of 2'-hydroxyls to the cleavage activity of the Neurospora VS ribozyme [PDF]
, 2002 Vanita D. Sood
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Études d'ingénierie du ribozyme VS de Neurospora
, 2015 Julie Lacroix‐Labonté
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An important role of G638 in the cis -cleavage reaction of the Neurospora VS ribozyme revealed by a novel nucleotide analog incorporation method [PDF]
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Crystal structure of the Varkud satellite ribozyme. [PDF]
Nat Chem Biol, 2015 Suslov NB +6 more
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Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid–base catalysis? A critical assessment of available experimental data [PDF]
, 2010 Timothy J. Wilson, David M.J. Lilley
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