Results 31 to 40 of about 6,175 (141)
Selfishness versus functional cooperation in a stochastic protocell model [PDF]
, 2010 How to design an "evolvable" artificial system capable to increase in complexity? Although Darwin's theory of evolution by natural selection obviously offers a firm foundation, little hope of success seems to be expected from the explanatory adequacy of ...
Agresti +56 more
core +2 more sources
The RNA Newton Polytope and Learnability of Energy Parameters [PDF]
, 2013 Despite nearly two scores of research on RNA secondary structure and RNA-RNA interaction prediction, the accuracy of the state-of-the-art algorithms are still far from satisfactory.
Chitsaz, Hamidreza +1 more
core +1 more source
Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junction [PDF]
The EMBO Journal, 2001 The VS nucleolytic ribozyme has a core comprising five helices organized by two three-way junctions. The ribozyme can act in trans on a hairpin-loop substrate, with which it interacts via tertiary contacts. We have determined that one of the junctions (2-3-6) undergoes two-stage ion-dependent folding into a stable conformation, and have determined the ...
Lafontaine, Daniel A. +2 more
openaire +4 more sources
Role of tautomerism in RNA biochemistry [PDF]
, 2015 Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchangeable protons.
Essigmann, John M. +2 more
core +1 more source
How RNA acts as a nuclease:some mechanistic comparisons in the nucleolytic ribozymes [PDF]
, 2017 Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic ...
Lilley, David M. J.
core +2 more sources
Large Phenotypic Enhancement of Structured Random RNA Pools. [PDF]
, 2020 Laboratory evolution of functional RNAs has applications in many areas of chemical and synthetic biology. In vitro selections critically depend on the presence of functional molecules, such as aptamers and ribozymes, in the starting sequence pools.
Chizzolini, Fabio +5 more
core
RNAi technology development for weed control: all smoke and no fire?
Pest Management Science, EarlyView.Despite the potential of Spray‐Induced Gene Silencing in weed management several critical points such as molecular target, weed species of interest as well as delivery techniques need to be addressed. Abstract RNA interference (RNAi) technology, specifically Spray‐Induced Gene Silencing (SIGS), holds potential as an innovative approach for selective ...
Silvia Panozzo +4 more
wiley +1 more source
Classification of the nucleolytic ribozymes based upon catalytic mechanism [PDF]
, 2019 The nucleolytic ribozymes carry out site-specific RNA cleavage reactions by nucleophilic attack of the 2’-oxygen atom on the adjacent phosphorus with an acceleration of a million-fold or greater.
A Ferré-D'Amaré +61 more
core +3 more sources
Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications
Small, EarlyView.Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin +2 more
wiley +1 more source
Method of identifying inhibitors of glutathione S-transferase (GST) gene expression [PDF]
, 1999 Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer.
Akande, Olanike +6 more
core +1 more source