Results 51 to 60 of about 6,175 (141)

General Acid–Base Catalysis Mediated by Nucleobases in the Hairpin Ribozyme [PDF]

, 2012
The catalytic mechanism by which the hairpin ribozyme accelerates cleavage or ligation of the phosphodiester backbone of RNA has been incompletely understood.
Kath-Schorr, Stephanie, Li, Nan Sheng, Lilley, David M. J., Lu, Jun, Piccirilli, Joseph A., Wilson, Timothy J.   +5 more
core   +2 more sources

Virus‐Assembled Biofunctional Microarrays with Hierarchical 3D Nano‐Reticular Network

Advanced Functional Materials, Volume 35, Issue 14, April 3, 2025.
Virus‐assembled microdots with a wrinkled pattern induced by the high‐pressure carbon dioxide method show a morphology similar to sunflowers. Abstract Three‐dimensional (3D) hierarchical wrinkled materials built with biological entities have so far remained exclusive to nature.
Lei Tian, Shadman Khan, Amid Shakeri, Kyle Jackson, Ahmed T. Saif, Fereshteh Bayat, Leon He, Jimmy Gu, Yingfu Li, Tohid F. Didar, Zeinab Hosseinidoust   +10 more
wiley   +1 more source

Robust self-replication of combinatorial information via crystal growth and scission [PDF]

, 2012
Understanding how a simple chemical system can accurately replicate combinatorial information, such as a sequence, is an important question for both the study of life in the universe and for the development of evolutionary molecular design techniques ...
B. Yurke, Bullard, Cairns-Smith, Carnall, Collins, Deck, Dutta, E. Winfree, Huppa, Johnston, Knowles, Mao, Orgel, Paul, R. Schulman, Rasmussen, Rothemund, Rothemund, Rubinov, Schrum, Seeman, Smalley, Smith, Viedma, Wang, Wang, Winfree, Wochner   +27 more
core   +3 more sources

The Critical Role of Inhibitor of Differentiation 4 in Breast Cancer: From Mammary Gland Development to Tumor Progression

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Inhibitor of differentiation 4 (ID4) is a highly conserved DNA‐binding inhibitory protein of mammals, and its main role is to bind basic helix–loop–helix (b‐HLH) so that it loses its DNA‐binding activity, which in turn regulates the transcription of key genes, regulating cell differentiation and proliferation as the physiological function ...
Yuhang Song, Panshi Zhang, Sudhanshu Bhushan, Xinhong Wu, Hongmei Zheng, Yalong Yang   +5 more
wiley   +1 more source

Aptamers in oncology: a diagnostic perspective [PDF]

, 2008
Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity.
Khan, Huma, Missailidis, Sotiris
core  

Forced-unfolding and force-quench refolding of RNA hairpins [PDF]

, 2006
Using coarse-grained model we have explored forced-unfolding of RNA hairpin as a function of $f_S$ and the loading rate ($r_f$). The simulations and theoretical analysis have been done without and with the handles that are explicitly modeled by ...
Barsegov, Bell, Best, Bishop, Bohbot-Raviv, Bustamante, Cate, Changbong Hyeon, Cocco, D. Thirumalai, Derenyi, Dima, Doudna, Ermack, Evans, Fernandez, Fernandez, Ferrenberg, Fersht, Gerland, Gerland, Hammond, Hummer, Hyeon, Hyeon, Khorasanizadeh, Klimov, Klimov, Krantz, Kumar, Lee, Lee, Leffler, Liphardt, Manosas, Mathews, Merkel, Misra, Mueller, Nevo, Nevo, Nymeyer, Onoa, Onoa, Reif, Rief, Rudisser, Sosnick, Sánchez, Thirumalai, Thirumalai, Tinoco, Veitshans, Walter, Zwanzig   +54 more
core   +3 more sources

Structural Biology of RNA and Protein‐RNA Complexes after AlphaFold3

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
AlphaFold is a great research accelerator and hypothesis generator for structural biology and beyond. With the release of AlphaFold3, RNA and protein‐RNA complex structure prediction is readily possible. This review assesses the reliability of these predictions.
Janosch Hennig
wiley   +1 more source

Structure of the ribozyme substrate hairpin of Neurospora VS RNA: A close look at the cleavage site

RNA, 2000
The cleavage site of the Neurospora VS RNA ribozyme is located in a separate hairpin domain containing a hexanucleotide internal loop with an A-C mismatch and two adjacent G-A mismatches. The solution structure of the internal loop and helix la of the ribozyme substrate hairpin has been determined by nuclear magnetic resonance (NMR) spectroscopy. The 2
Caroline H. J. Schouten, Paul J. A. Michiels, Hans A. Heus, Cornelis W. Hilbers   +3 more
openaire   +3 more sources

Properties and Cultivation of Fusarium spp. to Produce Mycoprotein as an Alternative Protein Source

Sustainable Food Proteins, Volume 3, Issue 1, March 2025.
This review explores the potential of Fusarium species in producing mycoprotein, a sustainable alternative protein source. It also delves into the origin of Fusarium species and its history related to mycoprotein production, nutrient assimilation, cultivation methods, nutritional and rheological properties, market presence, sustainability, and legal ...
Ramona Cheriaparambil, Lutz Grossmann
wiley   +1 more source

Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles. [PDF]

, 2018
Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those ...
Arizala, Jerlisa Ann C, Burnett, John C, Li, Haitang, Ouellet, Dominique L, Rossi, John J, Takahashi, Mayumi   +5 more
core   +1 more source