Results 51 to 60 of about 1,849,598 (165)

Defining the Parameters for Sorting of RNA Cargo Into Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
ABSTRACT Extracellular vesicles (EVs) are small particles that are released by cells and mediate cell–cell communication by transferring bioactive molecules such as RNA. RNA cargo of EVs, including coding and non‐coding RNAs, can change the behaviour of recipient cells, affecting processes including gene expression, proliferation, and Fapoptosis ...
Ahmed Abdelgawad, Yiyao Huang, Olesia Gololobova, Yanbao Yu, Kenneth W. Witwer, Vijay Parashar, Mona Batish   +6 more
wiley   +1 more source

A fast, efficient and sequence-independent method for flexible multiple segmental isotope labeling of RNA using ribozyme and RNase H cleavage [PDF]

, 2017
Structural information on RNA, emerging more and more as a major regulator in gene expression, dramatically lags behind compared with information on proteins.
Allain, Frédéric H.-T, Duss, Olivier, Maris, Christophe, von Schroetter, Christine   +3 more
core  

Understanding the errors of SHAPE-directed RNA structure modeling

, 2011
Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms.
Aviran S., Brunel C., Butler E. B., Byrne R. T., Cate J. H., Christopher C. VanLang, Collins K., Correll C. C., Cruz J. A., Darty K., Das R., Das R., Deigan K. E., Efron B., Efron B., Felsenstein J., Gesteland R. F., Hickey D. R., Hofacker I. L., Kladwang W., Kladwang W., Kulshina N., Kwon M., Lemay J. F., Leontis N. B., Levitt M., Mandal M., Mandal M., Mathews D. H., Mathews D. H., Mills D. R., Mitra S., Mortimer S. A., Noller H. F., Pablo Cordero, Panning B., Pedersen J. S., Regulski E. E., Rhiju Das, Russell R., Russell R., Serganov A., Smith K. D., Staley J. P., Sudarsan N., Sussman J. L., Takamoto K., Vasa S. M., Watts J. M., Wilkinson K. A., Wilkinson K. A., Winkler W. C., Wipapat Kladwang, Yoon S.   +53 more
core   +1 more source

RNAi technology development for weed control: all smoke and no fire?

Pest Management Science, Volume 81, Issue 7, Page 3430-3436, July 2025.
Despite the potential of Spray‐Induced Gene Silencing in weed management several critical points such as molecular target, weed species of interest as well as delivery techniques need to be addressed. Abstract RNA interference (RNAi) technology, specifically Spray‐Induced Gene Silencing (SIGS), holds potential as an innovative approach for selective ...
Silvia Panozzo, Andrea Milani, Serena Bordignon, Laura Scarabel, Serena Varotto   +4 more
wiley   +1 more source

Quasispecies evolution in general mean-field landscapes [PDF]

, 2001
I consider a class of fitness landscapes, in which the fitness is a function of a finite number of phenotypic "traits", which are themselves linear functions of the genotype.
Baake E., Bagnoli F., Franz S., Franz S., Gerland U., Goldstein Richard A., Krug J., L Peliti, Lemke N., Mitchell M.   +9 more
core   +1 more source

Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications

Small, Volume 21, Issue 27, July 10, 2025.
Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin, Xinghua Chen, Itamar Willner   +2 more
wiley   +1 more source

Role of tautomerism in RNA biochemistry [PDF]

, 2015
Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchangeable protons.
Essigmann, John M., Fedeles, Bogdan I., Singh, Vipender   +2 more
core   +1 more source

Christian Bohr. Discoverer of Homotropic and Heterotopic Allostery

Acta Physiologica, Volume 241, Issue S734, July 2025.
ABSTRACT This essay recounts and revisits the scientific contributions of Christian Bohr, highlighting his pivotal role in discovering allostery about 120 years ago. Bohr's meticulous experimentation led to identifying two distinct forms of allostery: homotropic (single‐ligand) and heterotropic (multi‐ligand), the latter widely recognized as the Bohr ...
Niels Bindslev
wiley   +1 more source

Ribozymes [PDF]

, 2009
Ribozimi su katalitičke molekule koje moraju biti savijene u visoko uređene tercijarne strukture, kao što to proteini rade da bi obavljali svoje funkcije. Glavni cilj je dovesti nukleofil i izrezujući fosfat u blizinu i aktivirati ih.
Zoko, Nikolina
core   +2 more sources

A mutate-and-map protocol for inferring base pairs in structured RNA

, 2013
Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling.
CS Chow, D Moazed, DH Mathews, EE Regulski, JB Lucks, JG Underwood, JP Staley, KA Wilkinson, M Kertesz, M Mandal, N Kulshina, NB Leontis, P Cordero, P Cordero, P Rocca-Serra, P Tijerina, PJ Lukavsky, R Rydzanicz, RC Spitale, RF Gesteland, S Mitra, S Washietl, S Yoon, SA Mortimer, SE Wells, SM Vasa, SW Brostoff, VD Sood, W Kladwang, W Kladwang, W Kladwang, W Kladwang, Y Rhee   +32 more
core   +1 more source