Results 71 to 80 of about 6,175 (141)

Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis

Annals of Clinical and Translational Neurology, Volume 11, Issue 12, Page 3054-3063, December 2024.
Abstract Antisense oligonucleotides, which are used to silence target genes, are gaining attention as a novel drug discovery modality for proteinopathies. However, while clinical trials for neurodegenerative diseases like amyotrophic lateral sclerosis have been conducted in recent years, the results have not always been favorable.
Daisuke Ito, Kensuke Okada
wiley   +1 more source

A fast, efficient and sequence-independent method for flexible multiple segmental isotope labeling of RNA using ribozyme and RNase H cleavage [PDF]

, 2017
Structural information on RNA, emerging more and more as a major regulator in gene expression, dramatically lags behind compared with information on proteins.
Allain, Frédéric H.-T, Duss, Olivier, Maris, Christophe, von Schroetter, Christine   +3 more
core  

Prostate transglutaminase (TGase-4) induces epithelial-to-mesenchymal transition in prostate cancer cells [PDF]

, 2017
More men die with prostate cancer (PCa) than from it. However, once PCa is no longer organ-confined, it is associated with significant mortality. Epithelial-to-mesenchymal transition (EMT) is one mechanism facilitating progression in cancer.
Ablin, Richard J, Jiang, Wen, Owen, Sioned   +2 more
core   +2 more sources

Études structurales par résonance magnétique nucléaire du ribozyme VS de Neurospora [PDF]

, 2015
Le ribozyme VS de Neurospora catalyse des réactions de clivage et de ligation d’un lien phosphodiester spécifique essentielles à son cycle de réplication. Il est formé de six régions hélicales (I à VI), qui se divisent en deux domaines, soit le substrat (
Bonneau, Éric
core  

Measuring the energy landscape roughness and the transition state location of biomolecules using single molecule mechanical unfolding experiments

, 2006
Single molecule mechanical unfolding experiments are beginning to provide profiles of the complex energy landscape of biomolecules. In order to obtain reliable estimates of the energy landscape characteristics it is necessary to combine the experimental ...
Changbong Hyeon, D Thirumalai, Derenyi I, Evans E, Fisher T E, Hummer G, Lide D R, Lu H, Ritort F, Zwanzig R   +9 more
core   +1 more source

Ribozymes [PDF]

, 2009
Ribozimi su katalitičke molekule koje moraju biti savijene u visoko uređene tercijarne strukture, kao što to proteini rade da bi obavljali svoje funkcije. Glavni cilj je dovesti nukleofil i izrezujući fosfat u blizinu i aktivirati ih.
Zoko, Nikolina
core   +2 more sources

Preparation of a Multi-Part Varkud Satellite Ribozyme Variant for Kinetics Studies [PDF]

, 2009
The Varkud Satellite (VS) ribozyme is the largest of the “small” nucleolytic ribozymes and is the only one for which there are no high resolution crystal structures available. The VS ribozyme comprises a catalytic domain and a substrate domain.
Chu, Allen Wing Ho
core  

Understanding the errors of SHAPE-directed RNA structure modeling

, 2011
Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms.
Aviran S., Brunel C., Butler E. B., Byrne R. T., Cate J. H., Christopher C. VanLang, Collins K., Correll C. C., Cruz J. A., Darty K., Das R., Das R., Deigan K. E., Efron B., Efron B., Felsenstein J., Gesteland R. F., Hickey D. R., Hofacker I. L., Kladwang W., Kladwang W., Kulshina N., Kwon M., Lemay J. F., Leontis N. B., Levitt M., Mandal M., Mandal M., Mathews D. H., Mathews D. H., Mills D. R., Mitra S., Mortimer S. A., Noller H. F., Pablo Cordero, Panning B., Pedersen J. S., Regulski E. E., Rhiju Das, Russell R., Russell R., Serganov A., Smith K. D., Staley J. P., Sudarsan N., Sussman J. L., Takamoto K., Vasa S. M., Watts J. M., Wilkinson K. A., Wilkinson K. A., Winkler W. C., Wipapat Kladwang, Yoon S.   +53 more
core   +1 more source

Optimal Random Libraries For the Isolation of Catalytic RNA [PDF]

, 2005
The relationship between ribozyme size and catalytic activity is of fundamental importance for RNA catalysis and molecular evolution in the RNA world.
Coleman, Tricia M., Huang, Faqing
core   +1 more source

Catalytic cleavage of an RNA substrate that bypasses the reorganization of its secondary structure during substrate recognition by a trans -acting VS ribozyme

Nucleosides, Nucleotides & Nucleic Acids
Varkud satellite ribozyme (VS ribozyme) is a class of catalytic RNA with self-cleavage activity. The wild-type VS ribozyme has structural modularity with a relatively large catalytic module (H2–H6 elements) and a small substrate module (H1 element). The two modules can be dissected physically, and the substrate H1 RNA is recognized and then cleaved by ...
Yuki Miyazaki, Ryu Nakane, Shogo Tanishi, Shigeyoshi Matsumura, Yoshiya Ikawa   +4 more
openaire   +2 more sources