Results 11 to 20 of about 293 (88)

Antagonistic activity against innate immunity determines virulence in mammalian bornaviruses [PDF]

npj Viruses
Variegated squirrel bornavirus 1 (VSBV-1) is a lethal emerging disease that has been discovered in privately owned and zoo squirrels, but its pathogenicity as a zoonotic pathogen remains uncertain.
Akiko Makino, Chiaki Tanaka, Kan Fujino, Keizo Tomonaga   +3 more
doaj   +2 more sources

Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011–2013 [PDF]

Emerging Infectious Diseases, 2019
Variegated squirrel bornavirus 1 (VSBV-1) is a zoonotic virus that causes fatal encephalitis in humans who are infected after contact with exotic squirrels.
Dennis Tappe, Jonas Schmidt-Chanasit, Jessica Rauch, Petra Allartz, Christiane Herden   +4 more
doaj   +2 more sources

Distribution of zoonotic variegated squirrel bornavirus 1 in naturally infected variegated and Prevost's squirrels. [PDF]

Sci Rep, 2019
Recently, the zoonotic capacity of the newly discovered variegated squirrel bornavirus 1 (VSBV-1) was confirmed in humans with a lethal encephalitis. Transmission to humans occurred by variegated and Prevost’s squirrels as presumed reservoir hosts but ...
Petzold J, van den Brand JMA, Nobach D, Hoffmann B, Hoffmann D, Fast C, Reusken CBEM, van Run PRWA, Schlottau K, Beer M, Herden C.   +10 more
europepmc   +3 more sources

Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013 [PDF]

Emerging Infectious Diseases, 2018
Limbic encephalitis is commonly regarded as an autoimmune-mediated disease. However, after the recent detection of zoonotic variegated squirrel bornavirus 1 in a Prevost’s squirrel (Callosciurus prevostii) in a zoo in northern Germany, we retrospectively
Dennis Tappe, Kore Schlottau, Daniel Cadar, Bernd Hoffmann, Lorenz Balke, Burkhard Bewig, Donata Hoffmann, Philip Eisermann, Helmut Fickenscher, Andi Krumbholz, Helmut Laufs, Monika Huhndorf, Maria Rosenthal, Walter Schulz-Schaeffer, Gabriele Ismer, Sven-Kevin Hotop, Mark Brönstrup, Anthonina Ott, Jonas Schmidt-Chanasit, Martin Beer   +19 more
doaj   +2 more sources

Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections. [PDF]

Cell Rep Med, 2022
Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of fatal BoDV-1 infection diagnosed on day 12 after hospitalization by ...
Neumann B, Angstwurm K, Linker RA, Knoll G, Eidenschink L, Rubbenstroth D, Schlottau K, Beer M, Schreiner P, Soutschek E, Böhmer MM, Lampl BMJ, Pregler M, Scheiter A, Evert K, Zoubaa S, Riemenschneider MJ, Asbach B, Gessner A, Niller HH, Schmidt B, Bauswein M.   +21 more
europepmc   +3 more sources

Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany. [PDF]

Sci Rep, 2019
Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany.
Tappe D, Frank C, Offergeld R, Wagner-Wiening C, Stark K, Rubbenstroth D, Giese S, Lattwein E, Schwemmle M, Beer M, Schmidt-Chanasit J, Wilking H.   +11 more
europepmc   +3 more sources

Borna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cells. [PDF]

Npj Viruses
Mammalian orthobornaviruses, such as Borna disease virus 1 (BoDV-1) and variegated squirrel bornavirus 1, are zoonotic pathogens that cause fatal encephalitis in humans.
Kanda T, Santos PD, Höper D, Beer M, Rubbenstroth D, Tomonaga K.   +5 more
europepmc   +3 more sources

The neuropathology of fatal encephalomyelitis in human Borna virus infection. [PDF]

Acta Neuropathol, 2019
After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the ...
Liesche F, Ruf V, Zoubaa S, Kaletka G, Rosati M, Rubbenstroth D, Herden C, Goehring L, Wunderlich S, Wachter MF, Rieder G, Lichtmannegger I, Permanetter W, Heckmann JG, Angstwurm K, Neumann B, Märkl B, Haschka S, Niller HH, Schmidt B, Jantsch J, Brochhausen C, Schlottau K, Ebinger A, Hemmer B, Riemenschneider MJ, Herms J, Beer M, Matiasek K, Schlegel J.   +29 more
europepmc   +3 more sources

Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus. [PDF]

Viruses, 2020
Adaptation of the viral life cycle to host cells is necessary for efficient viral infection and replication. This evolutionary process has contributed to the mechanism for determining the host range of viruses.
Komorizono R, Sassa Y, Horie M, Makino A, Tomonaga K.   +4 more
europepmc   +3 more sources

New World camelids are sentinels for the presence of Borna disease virus

Transboundary and Emerging Diseases, Volume 69, Issue 2, Page 451-464, March 2022., 2022
Abstract Borna disease (BD), a frequently fatal neurologic disorder caused by Borna disease virus 1 (BoDV‐1), has been observed for decades in horses, sheep, and other mammals in certain regions of Europe. The bicoloured white‐toothed shrew (Crocidura leucodon) was identified as a persistently infected species involved in virus transmission.
Alexandra J. Malbon, Ralf Dürrwald, Jolanta Kolodziejek, Norbert Nowotny, Ralph Kobera, Dietrich Pöhle, Aemero Muluneh, Eva Dervas, Christopher Cebra, Frank Steffen, Giulia Paternoster, Christian Gerspach, Monika Hilbe   +12 more
wiley   +1 more source