Results 131 to 140 of about 201,485 (360)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Structural Vulnerabilities and Currency Crises [PDF]
This paper examines the role of structural factors - governance and rule of law, corporate sector governance (creditor rights and shareholder rights), corporate financing structure - as well as macroeconomic variables in currency crises.
Atish R. Ghosh, Swati R. Ghosh
core
Detection of recurring software vulnerabilities [PDF]
, 2010 Software security vulnerabilities are discovered on an almost daily basis and have caused substantial damage. It is vital to be able to detect and resolve them as early as possible.
Pham, Nam
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Inducing and exploiting vulnerabilities for the treatment of liver cancer
Nature, 2019 Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies1,2; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatocellular carcinoma3.
Cun Wang +24 more
semanticscholar +1 more source
ASEAN Social Work JournalAge and Disability Consortium. (2018). Minimum standards for age and disability inclusion in humanitarian action. https://adstandards.org/ Cabauatan, R. J., Mendoza, A. V., & Torres, M. L. (2021). Disaster preparedness and disability inclusion: Gaps in
Kristoper Rex Oraiz, Elmee Joy Oraiz
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Tiding over socio-ecological vulnerabilities: experiences of two groups of cleaning/domestic women workers from Kerala, India [PDF]
This paper is a preliminary attempt to examine the experience of two groups of women cleaning/domestic workers in two cities in Kerala grappling with vulnerabilities induced by natural disasters and the pandemic. The groups are similar to each
J, Devika, Ajay, Anamika
core +1 more source
On Cyber Vulnerabilities Management in Critical Sectors: the Health Sector
Bulletin of "Carol I" National Defense UniversityThe digitalisation of the Romanian health sector has accelerated significantly, especially in the aftermath of the COVID-19 pandemic, but this transition has amplified cybersecurity risks, exposing critical infrastructures and patient data to persistent
Irina-Delia NEMOIANU
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source