Results 141 to 150 of about 201,485 (360)

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

open access: yesCell Reports, 2016
Summary Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have not changed for decades. To identify additional therapeutic targets in AML, we optimize a genome-wide clustered regularly interspaced
K. Tzelepis   +26 more
semanticscholar   +1 more source

Womenas Vulnerabilities Due to the Impact of Climate Change: Case from Satkhira Region of Bangladesh [PDF]

open access: yes, 2014
Bangladesh is recognized as one of the worst affected countries of the world due to climate induced disasters The disadvantageous geographical setting along with various socioeconomic factors is triggering the vulnerabilities of people The impacts of ...
Md. Sanaul Haque Mondal
core   +1 more source

Assessing technical aspects and vulnerabilities from Tswaing informal settlement in Hammanskraal, South Africa

open access: yesJàmbá
The increasing frequency of hazards such as floods, droughts, socio-political unrest, emerging diseases and rising temperatures has affected South Africa.
Davies V. Nkosi   +9 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Health vulnerabilities of undocumented central and Eastern European migrants in Switzerland [PDF]

open access: yes
Destitute undocumented Central and Eastern European migrants, who include homeless people, beggars, and sex workers, are in a highly vulnerable position in Switzerland. In the absence of residence permits, their access to health services and insurance is
Roduit, Sabrina   +2 more
core   +1 more source

Supply chain resilience and measurement dimensions: The case of halal pharmaceuticals in Malaysia

open access: yesSHS Web of Conferences, 2018
Resilience is the vital feature of supply chains that confers the ability to withstand the adverse effects of disruptive events. Most of the previous studies have been conceptual, theoretical, normative, or at best qualitative in approach, concentrating ...
Aigbogun Osaro   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Vulnerabilities of radiomic signature development: The need for safeguards.

open access: yesRadiotherapy and Oncology, 2019
PURPOSE Refinement of radiomic results and methodologies is required to ensure progression of the field. In this work, we establish a set of safeguards designed to improve and support current radiomic methodologies through detailed analysis of a radiomic
M. Welch   +10 more
semanticscholar   +1 more source

Denial of service attacks and challenges in broadband wireless networks [PDF]

open access: yes, 2008
Broadband wireless networks are providing internet and related services to end users. The three most important broadband wireless technologies are IEEE 802.11, IEEE 802.16, and Wireless Mesh Network (WMN).
Khan, S, Loo, KK, Naeem, T, Khan, MA
core  

Artificial intelligence tools for automating penetration testing

open access: yesТехнічна інженерія
The article discusses automated penetration testing using artificial intelligence (AI), which significantly enhances the efficiency and accuracy of cybersecurity assessments.
M.S. Koloshchuk   +3 more
doaj   +1 more source

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