Results 111 to 120 of about 950,912 (267)

Mapping South African farming sector vulnerability to climate change and variability: A subnational assessment [PDF]

open access: yes
"This paper analyzes the vulnerability of South African farmers to climate change and variability by developing a vulnerability index and comparing vulnerability indicators across the nine provinces of the country.
Gbetibouo, Glwadys Aymone   +1 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Evaluating different approaches to estimating vulnerability [PDF]

open access: yes
A number of researchers have recently proposed a variety of different `vulnerability'measures designed to capture the welfare consequences of risk for poor households, and also proposed a variety of different approaches to estimating these various ...
Ligon, Ethan, Schechter, Laura
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

VULNERABILITY OF URBAN INFORMAL SECTOR: STREET VENDORS IN YOGYAKARTA, INDONESIA [PDF]

open access: yes
This study has been focusing on the vulnerability of street vendors in Java since the time when Java was hit severely by the economic crisis in 1997/1998, which also had reversed the trend of economic formalization in Indonesia.
Aloysius Gunadi BRATA
core   +2 more sources

The impact of drought on household vulnerability: The case of rural Malawi [PDF]

open access: yes
Vulnerability to poverty in Malawi is highly associated with risk. Households face multiple shocks, most of which threaten their livelihoods and impact negatively on their welfare. Among the important risks that rural households face is drought, which is
Makoka, Donald
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Mapping Mediterranean bentho‐demersal communities to better inform marine conservation

open access: yesConservation Science and Practice
Marine conservation and spatial planning are seeing increasing interest by stakeholders at the local, regional and international levels to balance biodiversity protection, sustaining fisheries and accommodating new uses of the marine environment.
Miguel López   +4 more
doaj   +1 more source

Tomorrow's Hunger: A Framework for Analysing Vulnerability to Food Security [PDF]

open access: yes
food security, vulnerability, poverty, livelihoods, risks, risk ...
Knowles, Marco   +1 more
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

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