Results 91 to 100 of about 950,912 (267)

Economic Vulnerability and Resilience: Concepts and Measurements [PDF]

In this paper, economic vulnerability is defined as the exposure of an economy to exogenous shocks, arising out of economic openness, while economic resilience is defined as the policy-induced ability of an economy to withstand or recover from the ...
Vella, Stephanie, Cordina, Gordon, Farrugia, Nadia, Briguglio, Lino   +3 more
core  

Mobilizing Vulnerability in Scandinavian Art and Culture

, 2020
In this introductory chapter, the editors place the current volume within vulnerability scholarship—in particular, discussions by feminist thinkers who see vulnerability as more than a weakness.
Maria Karlsson, Mats Hyvönen, Adriana Margareta Dancus, Dancus, Adriana Margareta, Karlsson, Maria, Hyvönen, Mats, Hyvönen, Mats,, Karlsson, Maria,, Dancus, Adriana Margareta,   +8 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Measuring Ethiopian farmers' vulnerability to climate change across regional states: [PDF]

"This study analyzes the vulnerability of Ethiopian farmers to climate change based on the integrated vulnerability assessment approach using vulnerability indicators.
Hassan, Rashid M., Deressa, Temesgen, Ringler, Claudia   +2 more
core  

Regional vulnerability: the case of East Asia [PDF]

, 2006
In a case study of six East Asian economies, we use dynamic factor analysis to estimate a regional component of the exchange market pressure index (EMPI) as a measure of regional financial stress.
Mark P. Taylor, Mody, Ashoka, Taylor, Mark P., Ashoka Mody   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A conceptual framework to assess vulnerability. Application to global change stressors on South Indian farmers [PDF]

The objectives of the paper are (1) to apply Füssels (2007) conceptual framework of vulnerability to a concrete ongoing research and (2) to discuss on the resulting choice of an adequate vulnerability approach.
Stéphanie Aulong, Robert Kast
core  

Analysing vulnerability to volcanic hazards: application to St. Vincent [PDF]

, 2010
Volcanology and volcanic risk assessment have in the past been strongly biased towards pure physical sciences and the study of hazard mechanisms. Traditional vulnerability analyses undertaken at volcanoes have focused on the vulnerability of buildings
Lowe, C.J.
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Calculation model for the thickness limit of high-strength steel-concrete composite structures under the impact of slender thin-walled projectiles

Baozha yu Chongji
The study aims to solve the problem of calculating the thickness limit of high-strength steel-concrete composite structures under the impact of slender thin-walled projectiles, a key consideration for protective engineering design.
Qing ZHU, Shutao LI, Yeqing CHEN, Shang MA, Ruxing SHI, Xinshuang SONG   +5 more
doaj   +1 more source