Results 91 to 100 of about 2,945,640 (398)

Managing the post COVID-19 new normal: Redressing vulnerabilities of different occupational groups through social contract of public sector transparency and accountability

Progress in Disaster Science
The COVID-19 has had a significant impact on various occupational groups in Bangladesh, disrupting their fundamental necessities and everyday activities.
Shamima Prodhan, Khondoker Mokaddem Hossain, Md. Juel Mia   +2 more
doaj   +1 more source

Neuronal vulnerability and multilineage diversity in multiple sclerosis

Nature, 2019
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing–remitting disease course at early stages, distinct lesion characteristics in cortical grey versus subcortical white matter and neurodegeneration at chronic stages.
Lucas Schirmer, Dmitry Velmeshev, S. Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, J. Stockley, Adam M. H. Young, M. Steindel, Brian Tung, Nitasha Goyal, A. Bhaduri, Simone Mayer, J. B. Engler, O. Bayraktar, R. Franklin, M. Haeussler, R. Reynolds, D. Schafer, M. Friese, L. Shiow, A. Kriegstein, D. Rowitch   +23 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Communally established cattle feedlots as a sustainable livelihood option for climate change resilience and food security in sub-Saharan Africa: a systematic review

Frontiers in Sustainable Food Systems
Climate change poses a significant threat to agriculture and livestock production in sub-Saharan Africa, a region heavily reliant on livestock for smallholder farmers’ livelihoods.
Mhlangabezi Slayi, Leocadia Zhou, Patrick Nyambo, Ishmael Festus Jaja, Shadreck Muchaku   +4 more
doaj   +1 more source

Physical vulnerability to dynamic flooding: Vulnerability curves and vulnerability indices

Journal of Hydrology, 2022
Vulnerability analysis is crucial to assess natural hazard risk. Methods for vulnerability assessment include indices as well as vulnerability curves. Vulnerability curves make use of empirical data to show the relationship between the process intensity and the resulting degree of loss on each affected building whereas vulnerability indices are based ...
Maria Papathoma-Köhle, Matthias Schlögl, Lea Dosser, Florian Roesch, Marco Borga, Marcel Erlicher, Margreth Keiler, Sven Fuchs   +7 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Dynamic response mechanism and cumulative damage effect of Al0.3CoCrFeNi high-entropy alloy under repeated impact loading

Baozha yu Chongji
To investigate the evolution of phase structure, dislocation distribution, energy absorption capacity, and impact accumulation effect of high-entropy alloys (HEA) under shock loading, molecular dynamics simulations were employed to systematically analyze
Jialin CHEN, Shutao LI, Ming AN, Longyun ZHOU, Sheng ZHANG, Rongxin LI, Yeqing CHEN   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Mental health of undocumented migrants and migrants undergoing regularization in Switzerland: a cross-sectional study

BMC Psychiatry, 2021
Background Undocumented migrants live and work in precarious conditions. Few studies have explored the mental health consequences of such environment.
Julien Fakhoury, Claudine Burton-Jeangros, Liala Consoli, Aline Duvoisin, Delphine Courvoisier, Yves Jackson   +5 more
doaj   +1 more source