Results 101 to 110 of about 950,912 (267)
Commodity Price Volatility, Vulnerability and Development [PDF]
This paper examines the meaning and consequences of the developing countries economic vulnerability to the volatility of commodity prices. It first considers how to define and measure this vulnerability, which has three components, shocks, exposure and ...
Jean-Louis COMBES, Patrick GUILLAUMONT
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Trade Openness and Vulnerability in Central and Eastern Europe [PDF]
international trade, vulnerability, volatility, Central and Eastern European ...
Triulzi, Umberto +3 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Vulnerability to Poverty: A Microeconometric Approach and Application to the Republic of Haiti [PDF]
This paper investigates vulnerability to poverty in Haiti. Research in vulnerability in developing countries has been scarce due to the high data requirements of vulnerability studies (e.g. panel or long series of cross-sections). The methodology adopted
Evans Jadotte
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Vulnerability to Globalization in India: Relative Rankings of States Using Fuzzy Models [PDF]
globalization, vulnerability, fuzzy inference systems ...
Kumar, K.S. Kavi, Viswanathan, Brinda
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Vulnerability assessment using remote sensing: The earthquake prone megacity Istanbul, Turkey [PDF]
, 2007 Hazards like earthquakes are natural, disasters are not. Disasters result from the impact of a hazard on a vulnerable system or society at a specific location.
Taubenböck, Hannes +2 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source