Results 101 to 110 of about 2,945,640 (398)

Measuring Vulnerability [PDF]

open access: yesThe Economic Journal, 2003
Traditional poverty measures neglect several important dimensions of household welfare. In this paper we construct a measure of "vulnerability" which allows us to quantify the welfare loss associated with poverty as well as the loss associated with any of a variety of different sources of uncertainty.
Ligon, Ethan, Schechter, Laura
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

The role of adult socioeconomic and relational reserves regarding the effect of childhood misfortune on late-life depressive symptoms

open access: yesSSM: Population Health, 2019
Background: Childhood misfortune is associated with late-life depressive symptoms, but it remains an open question whether adult socioeconomic and relational reserves could reduce the association between childhood misfortune and late-life depressive ...
Martina von Arx   +10 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Prevalence and predictors of suicidal-risk behaviors among Paraguayan in-school adolescents: A sex-stratified analysis

open access: yesCurrent Research in Behavioral Sciences
This study performs a sex-stratified analysis of the prevalence and predictors of suicidal risk behaviors (SRBs) among Paraguayan adolescents, utilizing data from the 2017 Global School-based Student Health Survey (GSHS).
Taufique Ahmed   +2 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Sensuality [PDF]

open access: yes, 2018
My quilt is an intimate object that explores sexuality, feminism, beauty, and the vulnerability of women. I explored these topics through hand-stitching sensual images onto squares of fabric, which I then sewed into a quilt.
Slowik, Sara
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Analysis of the NIST database towards the composition of vulnerabilities in attack scenarios [PDF]

open access: yes, 2008
The composition of vulnerabilities in attack scenarios has been traditionally performed based on detailed pre- and post-conditions. Although very precise, this approach is dependent on human analysis, is time consuming, and not at all scalable.
Franqueira, Virginia Nunes Leal   +1 more
core   +2 more sources

Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

open access: yesEnvironmental Health Perspectives, 2000
Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes (i.e., proliferation, migration, differentiation,
D. Rice, S. Barone
semanticscholar   +1 more source

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