Results 61 to 70 of about 1,438,104 (293)

Ecological vulnerability assessment based on AHP-PSR method and analysis of its single parameter sensitivity and spatial autocorrelation for ecological protection – A case of Weifang City, China

Ecological Indicators, 2021
With the continuous development of society, the contradiction between human and nature becomes increasingly prominent, and ecological vulnerability assessment is an effective tool to alleviate the contradiction. In this study, AHP-PSR (Analytic Hierarchy
Xiaojing Hu, Chuanming Ma, Peng Huang, Xu Guo   +3 more
semanticscholar   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Does parent-child connectedness influence substance use among Bhutanese adolescents: evidence from a national survey?

BMC Public Health
Highlights • Tobacco use was highest, followed by alcohol and marijuana use. • The prevalence of substance use was higher in male than female adolescents.
Md. Tanvir Hasan Sojib, Md. Habibur Rahman, Md. Imamur Rashid Gogon, Md. Khalid Hasan   +3 more
doaj   +1 more source

Knowledge, attitude, and preparedness to respond to heat waves among informal workers in Dhaka, Bangladesh

Progress in Disaster Science
Heat waves pose a growing threat amid climate change, impacting human health and the environment. This study focuses on the Dhaka Metropolitan Area (DMA) to explore the knowledge, attitudes, and preparedness of informal workers regarding heat waves.
Sheikh Mohiuddin Shahrujjaman, Bivuti Bhushan Sikder, Dilara Zahid, Md Sohan Khan   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Neuronal vulnerability and multilineage diversity in multiple sclerosis

Nature, 2019
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing–remitting disease course at early stages, distinct lesion characteristics in cortical grey versus subcortical white matter and neurodegeneration at chronic stages.
Lucas Schirmer, Dmitry Velmeshev, S. Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, J. Stockley, Adam M. H. Young, M. Steindel, Brian Tung, Nitasha Goyal, A. Bhaduri, Simone Mayer, J. B. Engler, O. Bayraktar, R. Franklin, M. Haeussler, R. Reynolds, D. Schafer, M. Friese, L. Shiow, A. Kriegstein, D. Rowitch   +23 more
semanticscholar   +1 more source

Covid-19 and tourism vulnerability

Tourism Management Perspectives, 2021
The COVID-19 pandemic has dramatically impacted tourism and leisure activities worldwide, especially in the hospitality sector. This paper has a conceptual and empirical motivation based on two objectives.
J. Duro, Alejandro Pérez-Laborda, Judith Turrión-Prats, Melchor Fernández-Fernández   +3 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Managing the post COVID-19 new normal: Redressing vulnerabilities of different occupational groups through social contract of public sector transparency and accountability

Progress in Disaster Science
The COVID-19 has had a significant impact on various occupational groups in Bangladesh, disrupting their fundamental necessities and everyday activities.
Shamima Prodhan, Khondoker Mokaddem Hossain, Md. Juel Mia   +2 more
doaj   +1 more source