Results 91 to 100 of about 570,867 (306)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Entropy, 2019 Assessment and diagnosis of regional agricultural drought resilience (RADR) is an important groundwork to identify the shortcomings of regional agriculture to resist drought disasters accurately. In order to quantitatively assess the capacity of regional
Menglu Chen +5 more
doaj +1 more source
Effectiveness of Microfinance under SGSY scheme to reduce Poverty and Vulnerability of Rural Households: A Natural Experiment [PDF]
This paper shows that government of India supported microfinance programme under SGSY scheme is partially effective to reduce poverty of the rural households.
Kundu, Amit
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
An Economic Vulnerability Index: Its Design and Use for International Development Policy [PDF]
In response to the need expressed by the UN General Assembly, an economic vulnerability index (EVI) has been defined by the Committee for Development Policy.
Patrick Guillaumont
core +6 more sources
Journal of Water and Climate ChangeIn Morocco, the historical record depicts a situation characterized by increasing temperatures and diminishing precipitation, which often ends up in severe drought episodes.
Soumia Achli +4 more
doaj +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Addressing Coastal Vulnerability at the Village Level : The Role of Socio-economic and Physical Factors [PDF]
Vulnerability to extreme events is usually addressed for macro units (districts or provinces) whereas the relative vulnerability of micro units may be more useful to a policy maker.
Saudamini Das
core +1 more source
Vulnerability assessment of urban building stock: a hierarchic approach [PDF]
, 2012 In the last decades the evaluation of the seismic risk are of rising concern, considered essential in the activity and definition of strategy planning and urban management.
Costa, A. +4 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source