Results 31 to 40 of about 158,005 (264)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

A methodological framework for assessing the vulnerability of protected habitats and species to extreme weather events

Environmental Research Letters
Extreme weather events (EWEs) including storms, heatwaves, floods, droughts, wildfires, and cold snaps present an increasing threat to protected habitats and species (PHAS) as well as ecosystem services they provide.
Ashenafi Yohannes Battamo, M Kelly-Quinn, J J O’Sullivan, E Eichelmann, M A Habib, W Wei, M Salauddin   +6 more
doaj   +1 more source

Terrorism vulnerability assessment in Java Island: a spatial multi-criteria analysis approach

Indonesian Journal of Geography, 2020
Terrorism is one of the Indonesia’s national security threat. The attack mostly happens in Java Island, attracted by the dense population, also because the island is a center for economic and governance.
Asep Adang Supriyadi, Masita Dwi Mandini Manessa   +1 more
doaj   +1 more source

A vulnerability index formulation for the seismic vulnerability assessment of vernacular architecture [PDF]

Engineering Structures, 2019
Abstract The valorization and preservation of vernacular architecture, as well as traditional construction techniques and materials, is a key-element for cultural identity. Conservation efforts are often mainly focused on historical constructions and monuments.
Ortega, Javier, Vasconcelos, Graça, Rodrigues, Hugo, Correia, Mariana   +3 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The GDL Vulnerability Index (GVI) [PDF]

Social Indicators Research
AbstractIn this paper we present the GDL Vulnerability Index (GVI), a new composite index to monitor and analyse the human components of vulnerability to climate change, natural disasters, and other kinds of shocks, for societies and geographic areas across the globe.
Jeroen Smits, Janine Huisman
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source