Results 41 to 50 of about 158,005 (264)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Estimating the short-term economic impact of COVID-19 pandemic: A regional perspective

Geographia Polonica, 2021
Given the economic crisis related to the current COVID-19 pandemic, decision makers need to better understand how to effectively allocate their limited resources to support the most severely affected regions.
Zizi Goschin, Daniela-Luminita Constantin   +1 more
doaj   +1 more source

Vulnerabilities in distance-indexed IP traceback schemes [PDF]

International Journal of Security and Networks, 2007
In order to counter Denial-of-Service (DoS) attacks using spoofed source addresses, many IP traceback schemes have been proposed in the last few years. Among them, distance-indexed probabilistic packet marking schemes appear to be very attractive. In this paper, we first discover two intrinsic vulnerabilities in these schemes. Substantiated by efficacy
Jianping Pan 0001, Lin Cai 0001, Xuemin Shen   +2 more
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Landslide Disaster Risk for Small and Medium Agricultural Enterprises (SMAEs)

Environment and Natural Resources Journal
Small and Medium Agricultural Enterprises (SMAEs) are crucial for economic development in many developing countries, particularly in rural areas. Following a disaster, SMAEs experience the most profound impacts on their capital, logistics, workforce, and
Ngadisih, Bambang Purwantana, Devi Yuni Susanti, Ismi N. Puspitaningrum, Guruh Samodra, Peter Strauss, Sigit Supadmo Arif, Murtiningrum, Sri Rahayoe, Joko Nugroho W.K., Lilik Sutiarso, Nursigit Bintoro, Radi, Andri Prima Nugroho, Rizki Maftukhah, Rudiati Evi M., Chandra Setyawan, Bayu D.A. Nugroho, Prieskarinda Lestari   +18 more
doaj   +1 more source

Analysis of Earthquake Vulnerable Indicators in Exhausted Urban Tissue Case Study of Fakharan Neighborhood located in Kazerun County [PDF]

مهندسی و مدیریت ساخت, 2020
Currently, many cities in the country are facing a problem called worn-out texture. These textures are the old core of cities and have become worn out and inefficient over time, or formed in modern times without observing the rules and regulations of ...
Mohammadreza Ehsandoost, Ibrahim Zare
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Ship Traffic Disturbance Vulnerability Index for Northwest European Seabirds as a Tool for Marine Spatial Planning

Frontiers in Marine Science, 2019
Ship traffic in Northwestern European seas is intense and continuing to increase, posing a threat to vulnerable seabird species as a result of disturbance.
Katharina Leonia Fliessbach, Kai Borkenhagen, Nils Guse, Nele Markones, Philipp Schwemmer, Stefan Garthe   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source