Results 51 to 60 of about 158,005 (264)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Arctic Permafrost Vulnerability Index

Sustainability
As permafrost thaw accelerates, Arctic communities living on permafrost face new challenges that require the development of local adaptation policies. Vulnerability assessments have not yet been applied in the context of permafrost thaw. We develop a conceptual framework to assess vulnerabilities related to permafrost thaw in the Arctic Circumpolar ...
Ramage, Justine, Vasilevskaya, Anna, Heleniak, Timothy, Jungsberg, Leneisja, Cordier, Mateo, Stella, Elisa, Westermann, Sebastian, Larsen, Joan   +7 more
openaire   +4 more sources

Seismic risk assessment of algerian buildings in urban area

Journal of Civil Engineering and Management, 2013
The recent earthquakes in Algeria have caused significant human and economic losses. The frequent occurrence of damaging earthquakes clearly demonstrates the urgent need of study on seismic risk assessment methods of buildings to effectively reduce the ...
Fatima Zohra Baba Hamed, Driss Djaouad Rahal, Farid Rahal   +2 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Indice de vulnerabilidad estructural ante los efectos de remoción en masa en edificaciones de mampostería basado en conjuntos difusos Structural vulnerability index to the effects of landslides in masonry buildings based on fuzzy sets

Revista Ingeniería de Construcción, 2012
En este trabajo se presenta un modelo rápido y sencillo de evaluación de la vulnerabilidad estructural de edificaciones a escala regional. El modelo fue construido de forma que puede ser aplicado especialmente a zonas donde no se cuenta con información ...
Esperanza Maldonado Rondón, Gustavo Chio Cho   +1 more
doaj  

A Framework for Effective Multi-Hazard Risk Assessment in Post-Mining Areas

Safety
This work presents a structured methodology for multi-hazard risk assessment in post-mining coal areas, addressing the complex interactions between natural, mining, and technological hazards.
Dafni M. Nalmpant-Sarikaki, Alexandros I. Theocharis, Nikolaos C. Koukouzas, Ioannis E. Zevgolis   +3 more
doaj   +1 more source

Maternal Vulnerability Index and Severe Maternal Morbidity.

JAMA Netw Open
ImportanceFew studies have investigated the association of composite measures of neighborhood social determinants of health with severe maternal morbidity (SMM), and no research has examined this association for indices tailored to maternal health.ObjectiveTo examine the association of scores in the Maternal Vulnerability Index (MVI), a tool developed ...
Boghossian NS, Radack J, Passarella M, Phibbs CS, Greenberg LT, Buzas JS, Saade GR, Rogowski J, Lorch SA.   +8 more
europepmc   +3 more sources

A vulnerability index for climate related risks in Sweden

, 2021
<p>Social vulnerability is mostly described as specific social inequalities in the context of a disaster. Following this understanding, empirical research focuses on the unequal exposure of different groups to disasters and/or on the unequal capacities of groups to anticipate, cope and recover from the impact of a hazard.
Jan Haas, Konstantinos Karagiorgos, Lars Nyberg, Andreas Pettersson   +3 more
openaire   +3 more sources