Results 51 to 60 of about 581,731 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Heuristic Screening Aid for Consequential Life Cycle Assessment [PDF]

, 2017
Consequential life cycle assessment (CLCA) is envisioned as a framework that combines the technological richness of attributional life cycle assessment (ALCA) with basic economic intuition to assess the potential environmental impact of an innovation ...
Rajagopal, D
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Seismic vulnerability assessment of the old city centre of Seixal, Portugal [PDF]

, 2012
The seismic vulnerability assessment of old traditional masonry building stocks, in a seismic risk mitigation perspective, is truly essential not only for buildings with recognized historical and patrimonial value, but also, in relation to regular ...
Costa, A., Ferreira, T., Mendes da Silva, J. A. R., Varum, H., Vicente, R.   +4 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Landslide Disaster Risk for Small and Medium Agricultural Enterprises (SMAEs)

Environment and Natural Resources Journal
Small and Medium Agricultural Enterprises (SMAEs) are crucial for economic development in many developing countries, particularly in rural areas. Following a disaster, SMAEs experience the most profound impacts on their capital, logistics, workforce, and
Ngadisih, Bambang Purwantana, Devi Yuni Susanti, Ismi N. Puspitaningrum, Guruh Samodra, Peter Strauss, Sigit Supadmo Arif, Murtiningrum, Sri Rahayoe, Joko Nugroho W.K., Lilik Sutiarso, Nursigit Bintoro, Radi, Andri Prima Nugroho, Rizki Maftukhah, Rudiati Evi M., Chandra Setyawan, Bayu D.A. Nugroho, Prieskarinda Lestari   +18 more
doaj   +1 more source

Analysis of Earthquake Vulnerable Indicators in Exhausted Urban Tissue Case Study of Fakharan Neighborhood located in Kazerun County [PDF]

مهندسی و مدیریت ساخت, 2020
Currently, many cities in the country are facing a problem called worn-out texture. These textures are the old core of cities and have become worn out and inefficient over time, or formed in modern times without observing the rules and regulations of ...
Mohammadreza Ehsandoost, Ibrahim Zare
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source