Results 61 to 70 of about 581,731 (308)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A Ship Traffic Disturbance Vulnerability Index for Northwest European Seabirds as a Tool for Marine Spatial Planning

Frontiers in Marine Science, 2019
Ship traffic in Northwestern European seas is intense and continuing to increase, posing a threat to vulnerable seabird species as a result of disturbance.
Katharina Leonia Fliessbach, Kai Borkenhagen, Nils Guse, Nele Markones, Philipp Schwemmer, Stefan Garthe   +5 more
doaj   +1 more source

Coastal Vulnerability Index Analysis in the Anyer Beach Serang District, Banten [PDF]

, 2019
Anyer Beach is one of the famous tourist destinations. In addition to tourist destinations, the Anyer beach also has residential and industrial areas.
Amin, M. (Mawardi), Sebayang, I. S. (Ika), Sitompul, C. M. (Carolina)   +2 more
core  

MAPPING TSUNAMI VULNERABILITY FOR MATARAM CITY IN LOMBOK ISLAND – INDONESIA: A PHYSICAL AND SOCIOECONOMIC ASSESSMENT [PDF]

, 2015
Letak kedekatan lokasi geografis dengan lempeng tektonik Eurasian dan Indo-Australian membawa konsekuensi logis terhadap tingginya resiko kebencanaan, terutama gempa dan tsunami, bagi Indonesia.
Putra, Andhi Pratama
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Arctic Permafrost Vulnerability Index

Sustainability
As permafrost thaw accelerates, Arctic communities living on permafrost face new challenges that require the development of local adaptation policies. Vulnerability assessments have not yet been applied in the context of permafrost thaw. We develop a conceptual framework to assess vulnerabilities related to permafrost thaw in the Arctic Circumpolar ...
Ramage, Justine, Vasilevskaya, Anna, Heleniak, Timothy, Jungsberg, Leneisja, Cordier, Mateo, Stella, Elisa, Westermann, Sebastian, Larsen, Joan   +7 more
openaire   +2 more sources

Seismic risk assessment of algerian buildings in urban area

Journal of Civil Engineering and Management, 2013
The recent earthquakes in Algeria have caused significant human and economic losses. The frequent occurrence of damaging earthquakes clearly demonstrates the urgent need of study on seismic risk assessment methods of buildings to effectively reduce the ...
Fatima Zohra Baba Hamed, Driss Djaouad Rahal, Farid Rahal   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exposer Intensity, Vulnerability Index And Landscape Change Assessment In Olomouc, Czech Republic [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
The objective of this study is vulnerability and exposer intensity due to land use change in Olomouc, Czech Republic. Vulnerability assessment with exposer intensity to land use/cover change is an important step for enhancing the understanding and ...
M. S. Boori, V. Vozenilek, K. Choudhary
doaj   +1 more source