Results 61 to 70 of about 158,005 (264)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Assessment of Farm Vulnerability to Climate Change in Southern France

Land
Climate change (CC) is a major threat to agriculture, the sector that supports the territorial economy in the Pays Haut Languedoc et Vignoble (PHLV) region (south France).
Abderraouf Zaatra, Mélanie Requier-Desjardins, Hélène Rey-Valette, Thierry Blayac, Hatem Belhouchette   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Características anatómicas del tallo de bálsamo de incienso (Bursera tomentosa (Jacq.) Tr. & Planch.) Anatomical characteristics of the stem of Bursera tomentosa (Jacq.) Tr. & Planch.

Bioagro, 2005
Se describe la estructura anatómica del tallo de B. tomentosa a partir de muestras tomadas en plantas ubicadas en la zona de Tarabana, municipio Palavecino, estado Lara, Venezuela, en condiciones silvestres.
Maicol Castillo, María E Sanabria, Carelia Hidalgo, Yaritza Perozo   +3 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Country-Level Vulnerability in Maritime Bulk Commodity Supply Chains: An Integrated Framework for Identification, Monitoring, and Extrapolation

Systems
Against deglobalization and intensifying geopolitical conflicts, maritime bulk commodity supply chain vulnerability and resilience governance are strategic priorities for 75% of countries.
Lin Guo, Fangping Yu, Cong Sui, Mo Yang
doaj   +1 more source

Quantitative Assessment and Diagnosis for Regional Agricultural Drought Resilience Based on Set Pair Analysis and Connection Entropy

Entropy, 2019
Assessment and diagnosis of regional agricultural drought resilience (RADR) is an important groundwork to identify the shortcomings of regional agriculture to resist drought disasters accurately. In order to quantitatively assess the capacity of regional
Menglu Chen, Shaowei Ning, Yi Cui, Juliang Jin, Yuliang Zhou, Chengguo Wu   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Smallholder Farmers’ Vulnerability to Climate Variability in Different Agro-Ecological Zones of Legambo District, North-Central Ethiopia

Agriculture
Climate variability has adversely affected the agricultural production of smallholder farmers in developing countries like Ethiopia. This study aims to examine the overall vulnerability of smallholder farmers to climate variability in different agro ...
Kindalem Gebre Goshu, Fekadie Bazie Enyew, Sisay E. Debele, Gashaw Bimrew Tarekegn   +3 more
doaj   +1 more source