Results 81 to 90 of about 570,867 (306)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Assessment of Farm Vulnerability to Climate Change in Southern France

Land
Climate change (CC) is a major threat to agriculture, the sector that supports the territorial economy in the Pays Haut Languedoc et Vignoble (PHLV) region (south France).
Abderraouf Zaatra, Mélanie Requier-Desjardins, Hélène Rey-Valette, Thierry Blayac, Hatem Belhouchette   +4 more
doaj   +1 more source

Spatially explicit groundwater vulnerability assessment to support the implementation of the Water Framework Directive – a practical approach with stakeholders [PDF]

, 2008
The main objective of the study presented in this paper was to develop an evaluation scheme which is suitable for spatially explicit groundwater vulnerability assessment according to the Water Framework Directive (WFD).
Berkhoff, Karin
core  

Proposed Occupational Vulnerability Index COVID-19

Occupational Diseases and Environmental Medicine, 2020
[EN] Introduction: Vulnerable is someone who can be hurt or receive injury, physically or morally. The work environment appears as one of the dimensions in which social vulnerability develops and social and occupational vulnerability is defined. The literature does not include an assessment of quantified occupational vulnerability as it already exists ...
Vicente-Herrero, Mª Teófila, Ramírez Íñiguez de la Torre, Mª Victoria, Del Campo Balsa, Mª Teresa, Reinoso Barbero, Luis, Rueda Garrido, Juan Carlos, Santamaria Navarro, Cristina   +5 more
openaire   +3 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Características anatómicas del tallo de bálsamo de incienso (Bursera tomentosa (Jacq.) Tr. & Planch.) Anatomical characteristics of the stem of Bursera tomentosa (Jacq.) Tr. & Planch.

Bioagro, 2005
Se describe la estructura anatómica del tallo de B. tomentosa a partir de muestras tomadas en plantas ubicadas en la zona de Tarabana, municipio Palavecino, estado Lara, Venezuela, en condiciones silvestres.
Maicol Castillo, María E Sanabria, Carelia Hidalgo, Yaritza Perozo   +3 more
doaj  

Mapping social vulnerability to flood hazard in Norfolk, England [PDF]

, 2015
In this paper, we present a method to assess social vulnerability through the creation of an Open Source Vulnerability Index (OS-VI). The OS-VI provides context to environmental hazards and allows NGOs and local agencies to better tailor services and ...
Ellul, C, Fujiyama, T, Garbutt, K
core   +1 more source

Targeting attention on local vulnerabilities using an integrated index approach: the example of the climate vulnerability index

Water Science and Technology, 2005
It is known that climate impacts can have significant effects on the environment, societies and economies. For human populations, climate change impacts can be devastating, giving rise to economic disruption and mass migration as agricultural systems fail, either through drought or floods.
Sullivan, Caroline A, Meigh, Jeremy R
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source