Results 151 to 160 of about 19,845 (173)

Dyslipidemia and the vulnerable plaque

Progress in Cardiovascular Diseases, 2002
In the last decade, an increasingly sophisticated understanding of the pathogenesis of atherosclerosis and its cardiovascular consequences has emerged. The characteristics of the unstable atherosclerotic plaque, the substrate for the majority of acute coronary events, have been well defined: mild-to-moderate stenosis, a lipid-rich pool, few smooth ...
John A. Farmer, Antonio M. Gotto
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The Vulnerable Coronary Plaque

The Journal of Cardiovascular Nursing, 2000
Vulnerable coronary plaques are asymptomatic atherosclerotic lesions with the tendency to rupture. Plaque rupture is the initiating event in most acute coronary syndromes including sudden cardiac death, acute myocardial infarction, and unstable angina. Vulnerable plaques are commonly found in coronary arteries at autopsy but are virtually undetectable ...
Ellen McErlean, Steven E. Nissen, Paul Schoenhagen   +2 more
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Statins and Vulnerable Plaque

Current Pharmaceutical Design, 2018
Background: Atherosclerosis is a systemic, progressive lipid-driven inflammatory disease of the arterial vascular wall leading progressively to plaque development. The vulnerable plaque, the one considered to be the leading cause of cardiovascular events seems to exhibit a large and soft lipid-rich necrotic core covered by a thin and inflamed fibrous
Maria Drakopoulou, Dimitrios Tousoulis, Konstantinos Toutouzas, Archontoula Michelongona   +3 more
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Vulnerable Plaque Imaging

Neuroimaging Clinics of North America, 2005
The concept of vulnerable plaque is well established with increasing evidence from clinical and basic research. The paradigm has shifted from focusing exclusively on the hemodynamic effects of plaque (ie, resulting lumenal stenosis alone as a predictor of stroke risk) to assessment of the structure and composition of plaque (eg, denuded endothelium ...
Bruce A. Wasserman, John W. Chen
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From Vulnerable Plaque to Vulnerable Patient: The Search for Biomarkers of Plaque Destabilization

Trends in Cardiovascular Medicine, 2007
There is a strong need for biomarkers to identify patients at risk for future cardiovascular events related with progressive atherosclerotic disease. Ideally, increasing knowledge of the mechanisms of atherosclerotic plaque destabilization should be translated in clinical practice. Currently, the following commonly followed strategies can be identified
Frans L. Moll, Gerard Pasterkamp, Wouter Peeters, Willem E. Hellings   +3 more
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Inflammation and Plaque Vulnerability

Cardiovascular Drugs and Therapy, 2008
Development of a thrombus at the site of an atherosclerotic plaque initiates abrupt arterial occlusion and is the proximate event responsible for the vast majority of acute ischemic syndromes. In nearly 75% of cases thrombus overlies a disrupted or ruptured plaque whereas the remainder of the thrombi overly an intact plaque with superficial endothelial
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Vulnerable plaque: The biomechanics of matter

Atherosclerosis, 2014
Despite the considerable progress that has been made in cardiology over the last four decades through intensive risk-factor modification and life-style changes, cardiovascular disease prevalence, morbidity andmortality remain high [1]. One coronary event occurs every 34 s leading to one death every 83 s in the United States [2].
Jolanda J. Wentzel, George D. Giannoglou, Yiannis S. Chatzizisis, Antonios P. Antoniadis   +3 more
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From vulnerable plaque to atherothrombosis

Journal of Internal Medicine, 2008
Abstract.Plaque rupture precipitates approximately 75% of all fatal coronary thrombi. Therefore, the plaque prone to rupture is the primary focus of this review. The lipid‐rich core and fibrous cap are pivotal in the understanding of plaque rupture.
Thim, T, Hagensen, Mette, Bentzon, J F, Falk, E   +3 more
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Detection of Vulnerable Plaque

2019
The use of optical coherence tomography (OCT) imaging in research and clinical practice has provided useful insights into the pathobiology of the “vulnerable plaque” and acute coronary syndromes (ACS). Although thin-cap fibroatheroma (TCFA), defined as a lipid-rich plaque covered by a thin (i.e.,
Vergallo R, Jang IK
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Molecular Imaging of Vulnerable Plaque

Seminars in Nuclear Medicine, 2018
Molecular imaging provides multiple imaging techniques to identify characteristics of vulnerable plaque including I) Inflammatory cells (the presence and metabolic activity of macrophages), II) synthesis of lipid and fatty acid in the plaque, III) the presence of hypoxia in severely inflamed lesions, IV) expression of factors stimulating angiogenesis ...
Jagat Narula, Takehiro Nakahara, Takehiro Nakahara, Takehiro Nakahara, H. William Strauss, H. William Strauss   +5 more
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