Results 191 to 200 of about 78,688 (294)

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Perspectives in the Diagnosis, Clinical Impact, and Management of the Vulnerable Plaque. [PDF]

J Clin Med
Alperi A, Antuna P, Almendárez M, Álvarez R, Del Valle R, Pascual I, Hernández-Vaquero D, Avanzas P.   +7 more
europepmc   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Preventive percutaneous coronary intervention versus optimal medical therapy for vulnerable plaque: a meta-analysis. [PDF]

BMC Cardiovasc Disord
Chen Y, Liu X, Qiu Y, Guo Q, Zhang F, Nie S, Liu H, Long D, Wang X.   +8 more
europepmc   +1 more source

Establishment of a Novel Mouse Model for Atherosclerotic Vulnerable Plaque. [PDF]

Front Cardiovasc Med, 2021
Wang X, Fu Y, Xie Z, Cao M, Qu W, Xi X, Zhong S, Piao M, Peng X, Jia Y, Meng L, Tian J.   +11 more
europepmc   +1 more source

Effects of Regular Dual‐Light Antibacterial Photodynamic Therapy on Oral Health in Assisted Living Residents—A Randomized Controlled Trial

Gerodontology, EarlyView.
ABSTRACT Objective The objective of this study is to investigate the effect of dual‐light antimicrobial photodynamic therapy (aPDT) on oral health among older people living in assisted living facilities (ALF), comparing it to conventional oral self‐care guidance.
Wilma Romppanen, Jaana Helenius‐Hietala, Saila Pakarinen, Sanna Korte, Riitta Saarela, Anna Maria Heikkinen, Timo Sorsa, Tommi Pätilä   +7 more
wiley   +1 more source

Safety and Efficacy of Drug-Coated Balloons in Patients with Acute Coronary Syndromes and Vulnerable Plaque. [PDF]

Clin Appl Thromb Hemost, 2022
Zhang YB, Liu HD, Xing JH, Chen BW, Zhao YY, Gu HP, Tao HL.   +6 more
europepmc   +1 more source

Association Between Regular Dental Scaling and Risk of Dementia in Patients With Moderate to Severe Periodontitis Longitudinal Study Using Korean National Health Insurance Service‐National Health Screening Cohort Data Base

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives This study aimed to determine the effectiveness of regular dental scaling by evaluating the association between the frequency of dental scaling and the risk of dementia in individuals with moderate to severe periodontal disease. Methods This study used the Korean National Health Insurance Service‐National Health Screening cohort ...
Seon‐Rye Kim, Minkook Son, Yu‐Rin Kim   +2 more
wiley   +1 more source

Debate: Preventive coronary intervention for vulnerable plaque. The clinical cardiologist's approach. [PDF]

REC Interv Cardiol
Fernández-Olmo R.
europepmc   +1 more source