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Postpartum Acquired Hemophilia A in Two Women With Previously Undiagnosed Carrier Status for von Willebrand Disease Type 2N and Heterozygous p.R854Q Mutation. [PDF]

Haemophilia
Weise M, Klöter T, Keller M, Petros S, Pfrepper C.   +4 more
europepmc   +1 more source

Uptake of vWF–Anti-vWF Complexes by Platelets in Suspension

Arteriosclerosis, Thrombosis, and Vascular Biology, 1996
Efforts to identify the translocation of glycoprotein (GP) Ib/IX receptors, either bound to von Willebrand factor (vWF) or not, from exposed surfaces to interior membranes of thrombin-activated platelets in suspension have been unsuccessful. To observe vWF uptake by platelets, we added an anti-vWF antibody and staphylococcal protein A–gold (to act as a
J G White, M D Krumwiede, Gines Escolar
exaly   +4 more sources

Sequence Alignment between vWF and Peptides Inhibiting the vWF-collagen Interaction Does not Result in the Identification of a Collagen-binding Site in vWF

Thrombosis and Haemostasis, 2000
SummaryWe previously found that two peptides (N- and Q-peptide) selected by phage display for binding to an anti-vWF antibody, were able to inhibit vWF-binding to collagen (1). The sequence of those peptides could be aligned with the sequence in vWF at position 1129-1136 just outside the A3-domain.
Vanhoorelbeke, K., van der Plas, R.M., Vandecasteele, G., Vauterin, S., Huizinga, E.G., Sixma, J.J., Deckmijn, H.   +6 more
openaire   +4 more sources

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Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage

Blood, 2003
Von Willebrand factor (VWF) is synthesized in endothelial cells, where it is stored in Weibel-Palade bodies. Administration of 1-desamino-8-D-arginine-vasopressin (DDAVP) to patients with type 1 von Willebrand disease and to healthy individuals causes a rapid increase in plasma VWF levels.
Sandra L, Haberichter, Paula, Jacobi, Robert R, Montgomery   +2 more
openaire   +2 more sources

[The Effect of VWF Propeptide on VWF Mutant in D1 Domain].

Zhongguo shi yan xue ye xue za zhi, 2022
To investigate whether co-transfection of wild-type VWFpp with VWF mutant in D1 region is able to correct VWF defects in biosynthesis and secretion.Four VWF mutant plasmids were single transfected into HEK 293 cells, or co-transfected into HEK 293 cells with the wild type VWFpp plasmids.
Xiu-Qun, Yu, Zhen-Ni, Ma, Jing, Ling, Yun-Xiao, Zhao, Jie, Yin, Zi-Qiang, Yu, Chang-Geng, Ruan   +6 more
openaire   +1 more source

The smaller, the better: VWF in stroke

Blood, 2010
In this issue of Blood , Fujioka and colleagues demonstrate that the von Willebrand factor–cleaving protease ADAMTS13 limits brain infarction in a murine model of ischemic stroke.[1][1] Platelet aggregation at sites of vascular injury is essential for normal hemostasis but also causes ...
Bernhard, Nieswandt, Guido, Stoll
openaire   +2 more sources