Results 91 to 100 of about 61,670 (295)
Von Willebrand Factor and ADAMTS13 in COVID-19 and Beyond: A Question of Balance
European Medical Journal Nephrology, 2021 von Willebrand factor (VWF) is a large, adhesive, multimeric protein involved in haemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein. A deficiency or defect in VWF can lead to von Willebrand disease
Emmanuel J Favaloro +2 more
doaj
Interdisciplinary Medicine, EarlyView.This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang +8 more
wiley +1 more source
Interaction between VWF and FVIII in treating VWD
, 2015 In patients with von Willebrand disease (VWD), the absence of von Willebrand factor (VWF) antigen leads to the premature loss of endogenous circulating secreted factor VIII (FVIII), thereby resulting in the dual defect in haemostasis.
Berntorp, Erik, +2 more
core +2 more sources
Haematologica, 2010 Background Type 2B von Willebrand factor (VWF) is characterized by gain of function mutations in the A1 domain inducing a greater affinity for platelet GPIb, possibly associated with the disappearance of large VWF multimers and thrombocytopenia.Design ...
Alessandra Casonato +7 more
doaj +1 more source
Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions
Portal Hypertension &Cirrhosis, EarlyView.This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley +1 more source
Autosomal dominant C1149R von Willebrand disease: phenotypic findings and their implications
Haematologica, 2009 Background Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD).Design and Methods Eight patients from three unrelated families with this mutation were included in
Almudena Pérez-Rodríguez +5 more
doaj +1 more source
Phytotherapy Research, EarlyView.Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan +8 more
wiley +1 more source
Identification of intracellular VWF.
, 2013 (A) ELISA assay showing reactivity of different antibodies to VWF. VWF was allowed to bind collagen coated wells and antibodies raised against ADAMTS13 (BL154G, Wh2-22-1A and Wh2-11-1) [35], VWF (MO616, A0082 and AXL205) or the anti-V5 (V5) as well as ...
Tanvi Gupta (371279) +11 more
core +1 more source
Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events
Phytotherapy Research, EarlyView.An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia +1 more
wiley +1 more source
Phytotherapy Research, EarlyView.Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia +6 more
wiley +1 more source