Results 31 to 40 of about 47,556 (256)

Comparative analysis of TRPM8 gene and COPD markers expression in rat lungs following exposure to cigarette smoke and tobacco aerosol

Acta Biomedica Scientifica
Background. Chronic Obstructive Pulmonary Disease (COPD) remains a global medical and social problem. The ion channel TRPM8, a cold receptor, is known to be involved in the pathogenesis of the disease.
P. D. Timkin, M. A. Kiselev, D. A. Shapovalova, D. E. Naumov, P. M. Linskaya, E. A. Borodin   +5 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

Research and Practice in Thrombosis and Haemostasis, 2020
Background Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, caused by quantitative and qualitative changes in von Willebrand factor (VWF).
Jessica Garcia, Veronica H. Flood, Sandra L. Haberichter, Scot A. Fahs, Jeremy G. Mattson, Aron M. Geurts, Mark Zogg, Hartmut Weiler, Qizhen Shi, Robert R. Montgomery   +9 more
doaj   +1 more source

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Elevated Plasma von Willebrand Factor Antigen and Activity Levels Are Associated With the Severity of Coronary Stenosis

Clinical and Applied Thrombosis/Hemostasis, 2020
von Willebrand factor (VWF) acts as a bridge between platelets and the subendothelial matrix following vessel damage and plays a vital role in coronary artery disease (CAD).
Bin Yan MS, Qi Wang MS, Weipeng Du BS, Suping Zhai BS, Chaoyang Gou MS, Tianxi Hu BS, Lijun Xia PhD, Changgeng Ruan PhD, Yiming Zhao PhD   +8 more
doaj   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

On the issue of recurrent thrombosis in cancer patients

Акушерство, гинекология и репродукция
Aim: to identify the key pathogenic factors and triggers associated with recurrent venous thromboembolic events (VTE) in gynaecological oncology patients.Materials and Methods.
K. N. Grigoreva, V. O. Bitsadze, A. V. Vorobev, A. G. Solopova, J. Kh. Khizroeva, A. Z. Iakubov, J. Yu. Ungiadze, I. S. Kalashnikova, D. O. Utkin, D. V. Blinov, J.-C. Gris, I. Elalamy, G. Gerotziafas, A. D. Makatsariya   +13 more
doaj   +1 more source

The heads and the tails of malaria and VWF [PDF]

Blood, 2016
In this issue of Blood, O'Regan et al have extended our understanding of von Willebrand factor (VWF) in the pathogenesis of malaria. According to the World Health Organization (http://www.who.int/gho/malaria/en/), malaria affects 3.2 billion people in 97 countries with 198 million cases having occurred in 2013, and of those, 584 000 died.
openaire   +2 more sources

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source