Results 121 to 130 of about 61,670 (295)

Protein-electrophoretic studies on VWF-transfected HEK293 cells and human serum samples:

, 2014
(A) SDS-PAGE electrophoresis and subsequent western blotting (WB) and visualization using anti-VWF: (lane 1) cell lysates of recombinant wild-type VWF (rVWF-WT)-transfected HEK293 cells, (lane 2) mock-transfected HEK293 cells.
Julia Driesen (539613), Christiane Esch (539616), Susanne Steiner (539615), Jörg Bedorf (539617), Diane Goltz (539610), Hans-Peter Fischer (214145), Kanishka Hittetiya (539611), Hamideh Yadegari (539612), Thomas Neuhaus (539614), Hans-Jörg Hertfelder (539618), Jutta Kirfel (210681)   +10 more
core   +1 more source

Single‐Cell and Spatial Analysis Reveal the Differences Between Left‐Sided and Right‐Sided Colorectal Cancer

Cell Proliferation, EarlyView.
Single‐cell and spatial analysis revealed distinct CRC microenvironments by tumour laterality. Right‐sided tumours showed enhanced germinal centre B cells, CXCL13+ T cells, and organized TLS‐immune crosstalk via CCL19/21‐CCR7, suggesting better immunotherapy response.
Zongnai Zhang, Jiaqi Xu, Yingchao Wu, Tao Liu, Junling Zhang, Mai Zhou, Jie Qiao, Heng Pan, Xin Wang   +8 more
wiley   +1 more source

Muscle morphology and intramuscular fat after treatment‐as‐usual including botulinum neurotoxin A injections in children with cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Normalized muscle volume remained unchanged in all evaluated muscles after the 12‐month treatment‐as‐usual in children with cerebral palsy. Higher intramuscular fat fraction was observed in the medial gastrocnemius, suggesting concurrent intramuscular fat infiltration.
Zhongzheng Wang, Antea Destro, Alexandra Åhblom, Sven Petersson, Ferdinand Von Walden, Eva Pontén, Cecilia Lidbeck, Ruoli Wang   +7 more
wiley   +1 more source

The burden of COVID‐19 in hospitalized people with diabetes mellitus in Brazil: Insights from four years of the pandemic

Diabetic Medicine, EarlyView.
Abstract Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is more severe in people with diabetes mellitus due to immune dysfunction, exacerbated inflammation and increased risk of co‐morbidities and mortality.
Taís Mendes Camargo, Bianca Aparecida Siqueira, Luiz Felipe Azevedo Marques, Lucas Silva Mello, Fernando Augusto Lima Marson   +4 more
wiley   +1 more source

The relationships between disseminated intravascular coagulation and time series change of Von Willebrand factor in patients with out-of-hospital cardiac arrest: a retrospective observational study

Thrombosis Journal
Background Out-of-hospital cardiac arrest (OHCA) is frequently complicated by disseminated intravascular coagulation (DIC), which worsens outcomes. Von Willebrand factor (VWF) is central to haemostasis, and its multimeric size and activity are regulated ...
Yuki Itagaki, Yuki Chiba, Misako Suzuki, Mariko Hayamizu, Hisanori Horiuchi, Mineji Hayakawa   +5 more
doaj   +1 more source

Expression of WT and mutant VWF in transfected HEK293 cells.

, 2013
VWF:Ag, VWF antigen; VWF:CB, VWF collagen-binding activity; WT, wild-type VWF; WT (1/2), one-half amount of WT plasmid; Data represent mean ± SD ...
Ningzheng Dong (328283), Changgeng Ruan (328282), Qingyu Wu (147511), Xiaojuan Zhao (328276), Zhenni Ma (328280), Sensen Shi (328278), Meng Liu (261774), Jing Dong (102657)   +7 more
core   +1 more source

Von Willebrand Factor and ADAMTS13 in Relation to Atherosclerosis in the General Population: The Rotterdam Study

European Journal of Haematology, EarlyView.
ABSTRACT Background Higher von Willebrand factor (VWF) levels and lower ADAMTS13 activity are linked to increased risk of atherosclerotic cardiovascular disease, but their association with atherosclerosis burden, a potential underlying mechanism, remains unclear.
Mitra Nekouei Shahraki, Frank W. G. Leebeek, Moniek P. M. de Maat, Maryam Kavousi, Daniel Bos   +4 more
wiley   +1 more source

Figure 5: Immunohistologic Staining for vWF

, 2019
Representative micrograph images of von Willebrand factor (vWF) immunohistochemistry staining on cross sections of silk grafts at 3 (A), 6 (B), 12 (C), and 24 (D) weeks. vWF staining is red, and 4′,6-diamidino-2-phenylindole staining is blue. Scale bar =
Nianji Yang (6821876), Jelena Rnjak-Kovacina (1356204), Elysse C. Filipe (761411), Juichien Hung (2590255), Alex H.P. Chan (4786665), Martin K.C. Ng (6820748), Steven G. Wise (761405), Bob S.L. Lee (4786662), Miguel Santos (748732)   +8 more
core   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

von Willebrand Factor fibers formed at pathological high shear provide a scaffold for α-synuclein binding and aggregation

Scientific Reports
α-Synuclein (αSyn) is an intrinsically disordered protein whose misfolding and aggregation promotes various synucleinopathies. Potentially relevant to the biophysics of αSyn-dependent pathology as well as seed amplification assays, we tested fibrous von ...
Jason M. Rossi, Scott L. Diamond
doaj   +1 more source