Results 261 to 270 of about 79,317 (281)

Rare onset of congenital thrombotic thrombocytopenic purpura during pregnancy: A novel ADAMTS13 gene variant

Transfusion, Volume 65, Issue 10, Page 1982-1988, October 2025.
Abstract Background Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare autosomal recessive thrombotic microangiopathy caused by biallelic mutations in ADAMTS13, leading to severe enzyme deficiency. The absence of ADAMTS13 prevents cleavage of ultra‐large von Willebrand factor multimers, resulting in platelet‐rich microthrombi formation ...
Rita González‐Resina, Mar Herrero‐Gutiérrez, Inés Gómez‐Seguí, Jorge Martínez‐Nieto, Ángeles Montañés, Ana Belén Roche Latasa, Valle Recasens   +6 more
wiley   +1 more source

COVID-19 Microangiopathy: Insights into plasma exchange as a therapeutic strategy. [PDF]

Hematol Transfus Cell Ther
Baykara Y, Sevgi K, Akgun Y.
europepmc   +1 more source

Multiomics investigation of the female hypertensive human heart

Physiological Reports, Volume 13, Issue 19, October 2025.
Abstract Hypertension affects 1 in 2 adults in the United States and is the leading risk factor for myocardial infarction and chronic kidney disease. While animal models have advanced our understanding of the effects of hypertension on the heart, molecular insight from human cardiovascular tissues is currently lacking.
Zachary J. Milstone, Jesse D. Moreira‐Bouchard, Karan K. Smith, Anjali Anilkumar, Adam C. Gower, Yuriy Alekseyev, Jason A. Cunha, Nathaniel Fisher, Levi Legler, Joshua Lepson, Brian S. Tao, Christopher Williams, Emelia J. Benjamin, Daniel Levy, Richard N. Mitchell, Robert F. Padera, Hardik Shah, Seung Hoan Choi, Deepa M. Gopal, Nathan R. Tucker, Jessica L. Fetterman   +20 more
wiley   +1 more source

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis. [PDF]

Blood Adv
Raghunath A, Richter CE, Griffin MS, Emly SM, Yaman M, Arruda VR, Samelson-Jones BJ, Shavit JA.   +7 more
europepmc   +1 more source

Development and Validation of a Liquid Chromatography High‐Resolution Mass Spectrometry Method for Blood Desmopressin Quantification and Its Application in Hemophilia A Patients

Rapid Communications in Mass Spectrometry, Volume 39, Issue 18, 30 September 2025.
ABSTRACT Desmopressin (DDAVP), which indirectly increases Coagulation Factor VIII concentrations in the blood, is a common treatment for bleeding disorders such as von Willebrand disease or hemophilia A. However, DDAVP exhibits significant variability in response due to interindividual differences in pharmacokinetics.
Sophie Hodin, Jean Escal, Catherine Feliu, Adeline Pontis, Laurie Josset, Adrian Serban, Benoît Guillet, Xavier Delavenne   +7 more
wiley   +1 more source

Overall leukocyte levels link risk factors to Von Willebrand factor and Neutrophil Extracellular Traps in stroke thrombi: a Structural Equation Modeling analysis. [PDF]

Front Neurol
Shi L, Wei C, Ye G, Zhao P, Ma S, Qi Y, Zhou R, Zhang Y, Zhang Y, Meng L, Xu W, Li C, Wang S, Sun L.   +13 more
europepmc   +1 more source

Factor deficiency in pregnancy and the role of the delta hemoglobin indices. [PDF]

Turk J Obstet Gynecol
İpek G, Tanaçan A, Altındiş Bal A, Yücel Yetişkin FD, Demet İ, Başaran E, Pekcan G, Şahin D.   +7 more
europepmc   +1 more source

Prognostic relevance of early clinical and laboratory findings in immune-mediated thrombotic thrombocytopenic purpura. [PDF]

Res Pract Thromb Haemost
Hamamura A, Sakai K, Mushino T, Ueda Y, Ogawa Y, Noguchi H, Okamoto A, Yagi H, Mori T, Matsumoto M.   +9 more
europepmc   +1 more source

A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche

Secchi MA, Liu Q, Antón SG, Mai C, Jibril A, Xu J, O’Carroll D, Wilson NK, Kranc KR, Göttgens B, Celso CL, Luis TC.   +11 more
europepmc   +1 more source

Profuse Bleeding From a Pyogenic Granuloma As the First Clue to von Willebrand Disease in a Pediatric Patient. [PDF]

Cureus
Moreno BA, Khatib Z, Duarte A.
europepmc   +1 more source