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Protein superglue that holds VWF together
Blood, 2014In this issue of Blood , Zhou and Springer report on the structure determination of the von Willebrand factor (VWF) C-terminal cysteine knot domain (CTCK), finally uncovering the structural basis for the super-stable CTCK dimer that underpins platelet adhesion.[1][1] ![Figure][2] VWF is ...
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Science Signaling, 2001
A hallmark of thrombotic thrombocytopenic purpura (TTP) is destruction of platelets and erythrocytes. It is thought that the greatly reduced proteolytic cleavage of von Willebrand factor [(VWF), a protein that is important for proper blood clotting] seen in TTP patients, provides a clue to the etiology of the disease.
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A hallmark of thrombotic thrombocytopenic purpura (TTP) is destruction of platelets and erythrocytes. It is thought that the greatly reduced proteolytic cleavage of von Willebrand factor [(VWF), a protein that is important for proper blood clotting] seen in TTP patients, provides a clue to the etiology of the disease.
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VWF, ADAMTS13, and acute coronary syndromes
Blood, 2016In this issue of Blood, Pedrazzini et al1 have taken an important step toward revitalizing our view of coronary artery thrombosis and providing a new target for the pharmacologic treatment of acute coronary syndromes (ACS).
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Sugar targets VWF for the chop
Blood, 2010In this issue of Blood , McGrath et al provide new insights into the influence of glycosylation on VWF proteolysis by ADAMTS13.[1][1] Von Willebrand factor (VWF) is synthesized in vascular endothelial cells and megakaryocytes and undergoes extensive processing prior to secretion.
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VWF attributes – impact on thrombus formation
Thrombosis Research, 2008At sites of vascular injury, free-flowing platelets attach to the vessel wall to initiate thrombus formation in areas of high haemodynamic shear stress, a process that is critical for both haemostasis and thrombosis. This reaction is mediated by the binding of the platelet glycoprotein (GP) Iba to the A1 domain of immobilized von Willebrand factor (VWF)
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VWF sequence variants: a data goldmine
Blood, 2013In this issue of Blood , Johnsen et al have analyzed the frequency of coding sequence variants in the von Willebrand factor gene ( VWF ) and have identified 7 missense variants independently associated with levels of von Willebrand factor (VWF) or factor VIII (FVIII).
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