Results 341 to 350 of about 104,334 (371)
Magnetostaltic pumping in an ex vivo extracorporeal membrane oxygenation model. [PDF]
J Transl MedZolala M +5 more
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Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage
Blood, 2003Von Willebrand factor (VWF) is synthesized in endothelial cells, where it is stored in Weibel-Palade bodies. Administration of 1-desamino-8-D-arginine-vasopressin (DDAVP) to patients with type 1 von Willebrand disease and to healthy individuals causes a rapid increase in plasma VWF levels.
Sandra L, Haberichter +2 more
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Uptake of vWF–Anti-vWF Complexes by Platelets in Suspension
Arteriosclerosis, Thrombosis, and Vascular Biology, 1996Efforts to identify the translocation of glycoprotein (GP) Ib/IX receptors, either bound to von Willebrand factor (vWF) or not, from exposed surfaces to interior membranes of thrombin-activated platelets in suspension have been unsuccessful. To observe vWF uptake by platelets, we added an anti-vWF antibody and staphylococcal protein A–gold (to act as a
J G, White +3 more
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Hämostaseologie, 1996
ZusammenfassungDie immunologische Bestimmung der von-Willebrand-Faktor-Konzentration ist ein wichtiger Baustein in der Strategie zur Diagnostik des von-Willebrand-Syn-droms. Mit dem hier vorgestellten Test, STA LIA vWF (Boehringer Mannheim GmbH) kann diese Bestimmung in der Routineanalytik innerhalb von 10 Minuten an den Gerinnungssystemen STA und STA ...
Ute Reimann, K.-E. Stötzer
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ZusammenfassungDie immunologische Bestimmung der von-Willebrand-Faktor-Konzentration ist ein wichtiger Baustein in der Strategie zur Diagnostik des von-Willebrand-Syn-droms. Mit dem hier vorgestellten Test, STA LIA vWF (Boehringer Mannheim GmbH) kann diese Bestimmung in der Routineanalytik innerhalb von 10 Minuten an den Gerinnungssystemen STA und STA ...
Ute Reimann, K.-E. Stötzer
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[The Effect of VWF Propeptide on VWF Mutant in D1 Domain].
Zhongguo shi yan xue ye xue za zhi, 2022To investigate whether co-transfection of wild-type VWFpp with VWF mutant in D1 region is able to correct VWF defects in biosynthesis and secretion.Four VWF mutant plasmids were single transfected into HEK 293 cells, or co-transfected into HEK 293 cells with the wild type VWFpp plasmids.
Xiu-Qun, Yu +6 more
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Oxidative stress on VWF proteolysis
Blood, 2010In this issue of Blood , Chen and colleagues demonstrate that the rate of cleaving VWF by ADAMTS13 is significantly slowed when the residue Met1606 in the VWF A2 domain is oxidized.[1][1] The finding adds a new dimension to the complexity of regulating VWF cleavage and links the rate of ...
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Thrombosis and Haemostasis, 1987
SummaryNine monoclonal antibodies (MAb, coded ESvWF 1-5, 7-10) to human von Willebrand’s factor (vWf) have been studied for their labelling characteristics with 125I and their ability to demonstrate vWf multimers by autoradiography after discontinuous SDS electrophoresis on agarose and agarose/acrylamide gels in plasma from normal and von Willebrand’s ...
M S, Enayat +4 more
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SummaryNine monoclonal antibodies (MAb, coded ESvWF 1-5, 7-10) to human von Willebrand’s factor (vWf) have been studied for their labelling characteristics with 125I and their ability to demonstrate vWf multimers by autoradiography after discontinuous SDS electrophoresis on agarose and agarose/acrylamide gels in plasma from normal and von Willebrand’s ...
M S, Enayat +4 more
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Science Signaling, 2001
A hallmark of thrombotic thrombocytopenic purpura (TTP) is destruction of platelets and erythrocytes. It is thought that the greatly reduced proteolytic cleavage of von Willebrand factor [(VWF), a protein that is important for proper blood clotting] seen in TTP patients, provides a clue to the etiology of the disease.
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A hallmark of thrombotic thrombocytopenic purpura (TTP) is destruction of platelets and erythrocytes. It is thought that the greatly reduced proteolytic cleavage of von Willebrand factor [(VWF), a protein that is important for proper blood clotting] seen in TTP patients, provides a clue to the etiology of the disease.
openaire +2 more sources