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VWF, ADAMTS13, and acute coronary syndromes

Blood, 2016
In this issue of Blood, Pedrazzini et al1 have taken an important step toward revitalizing our view of coronary artery thrombosis and providing a new target for the pharmacologic treatment of acute coronary syndromes (ACS).
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VWF attributes – impact on thrombus formation

Thrombosis Research, 2008
At sites of vascular injury, free-flowing platelets attach to the vessel wall to initiate thrombus formation in areas of high haemodynamic shear stress, a process that is critical for both haemostasis and thrombosis. This reaction is mediated by the binding of the platelet glycoprotein (GP) Iba to the A1 domain of immobilized von Willebrand factor (VWF)
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VWF sequence variants: a data goldmine

Blood, 2013
In this issue of Blood , Johnsen et al have analyzed the frequency of coding sequence variants in the von Willebrand factor gene ( VWF ) and have identified 7 missense variants independently associated with levels of von Willebrand factor (VWF) or factor VIII (FVIII).
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vWf

2006
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vWF

2008
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vWF

2011
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Transcatheter aortic valve implantation leads to a restoration of von Willebrand factor (VWF) abnormalities in patients with severe aortic stenosis - Incidence and relevance of clinical and subclinical VWF dysfunction in patients undergoing transfemoral TAVI.