Results 51 to 60 of about 84,707 (308)

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Comparison of Dried Blood Spot Sampling Methods for RNA‐Based Biomarker Measurement in Anti‐Doping

Drug Testing and Analysis, EarlyView.
This study demonstrates that RNA‐based biomarkers of erythropoiesis, ALAS2 and CA1, can be reliably quantified across commonly used DBS sampling matrices, including venous and capillary blood spotted on cellulose cards and the Tasso‐M20 device. ABSTRACT Dried blood spot (DBS) sampling offers logistical advantages, but it remains unexplored whether ...
Jacob Bejder, Corentin Schlechten, Claudia Mumenthaler, Olivier Salamin, Tiia Kuuranne, Thomas Christian Bonne, Jonathan Graae, Henrik Sørensen, Nikolai B. Nordsborg, Nicolas Leuenberger   +9 more
wiley   +1 more source

Elimination Profile of Deflazacort and Metabolites in Urine and Plasma Following Oral Administration: Relevance to Sports Drug Testing

Drug Testing and Analysis, EarlyView.
Results confirm that the MRL of 30 ng/mL for 21‐desacetyl‐deflazacort together with a 3‐day washout period is an appropriated strategy to detect oral deflazacort administration in sport competition. ABSTRACT Deflazacort (DEF) is a glucocorticoid prohibited in sports competitions when orally administered.
Sergi Coll, Claudia Bressan, Núria Monfort, Ana Aldea‐Perona, Marcel·lí Carbó, Rosa Ventura   +5 more
wiley   +1 more source

Data for Y. Wada et al. manuscript "Meteorological Aspects of Gamma-ray Glows in Winter Thunderstorms"

Materials used to produce figures in the manuscript entitled "Meteorological Aspects of Gamma-ray Glows in Winter Thunderstorms" (Y.
Wada, Y
core   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

Drug Testing and Analysis, EarlyView.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug, S. Guddat, C. Görgens, K. Walpurgis, F. Toma, A. Thomas, M. Thevis   +6 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine

Drug Testing and Analysis, EarlyView.
This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC‐HRMS/MS identified four tentative metabolites; maximum urinary concentrations reached 4 ng/mL within 4–48 h.
O. Krug, A. Thomas, M. Thevis
wiley   +1 more source

Identification of Synthetic Urine by Analysis of Stable Carbon and Nitrogen Isotope Ratios and Comparison to Established GC‐MS/MS and LC‐MS/MS Analysis

Drug Testing and Analysis, EarlyView.
This study compared GC‐MS/MS, EA‐IRMS, and LC‐MS/MS for detecting synthetic and manipulated urine samples in doping control and forensic analysis. EA‐IRMS proved particularly effective for identifying mixtures of synthetic and authentic urine, providing a reliable complement to established authenticity testing methods.
Hülsemann Frank, Franke Laura, Dirk K. Wissenbach, Fußhöller Gregor, Thevis Mario   +4 more
wiley   +1 more source

Detection of Testosterone Esters in Urine: Evidence of Trace‐Level Detectability in Doping Control Samples

Drug Testing and Analysis, EarlyView.
An ultrasensitive LC‐MS/MS method for detecting testosterone esters (T‐esters) in urine at sub–pg/mL levels is presented. This approach, employing Girard P derivatization, provides the first evidence of T‐esters' trace‐level detectability in human urine.
Daniel Pecher, Guro Forsdahl, Biljana Stojanovic, Günter Gmeiner   +3 more
wiley   +1 more source

Predicting post‐surgical visuospatial memory performance in people with drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Objective Although verbal memory decline has been consistently reported following surgery for temporal lobe epilepsy, especially when surgery is performed in the language‐dominant hemisphere and targets mesial temporal structures, the relation between the location and the hemisphere of surgery on visuospatial memory, as well as the factors ...
Emma Colucci, Arnaud Saj, Simon Charbonneau, Carole Denault, Annie Malenfant, Isabelle Rouleau, Dang Khoa Nguyen, Olivier Boucher   +7 more
wiley   +1 more source

Stereo‐EEG mapping of visual working memory with task‐related high‐gamma modulations

Epilepsia, EarlyView.
Abstract Objective We describe a safe, informative, and easy‐to‐implement approach for presurgical mapping of visual working memory (VWM) with stereo‐electroencephalography (SEEG). Methods Twenty‐four patients with drug‐resistant epilepsy, 11–23 years of age, performed a single‐probe change detection VWM task, during SEEG monitoring.
Brian Ervin, Jason Buroker, Taylor Cummins, Anna W. Byars, Craig Scholle, Leonid Rozhkov, Paul S. Horn, Jeffrey R. Tenney, Hansel M. Greiner, James L. Leach, Jesse Skoch, Francesco T. Mangano, Katherine D. Holland, Ravindra Arya   +13 more
wiley   +1 more source