Results 271 to 280 of about 1,068,340 (359)

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

open access: yesAdvanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu   +9 more
wiley   +1 more source

Social Determinants of the Transition in Food Consumption in Paraíba, Brazil, Between 2008 and 2018. [PDF]

open access: yesNutrients
de Oliveira SF   +8 more
europepmc   +1 more source

Minimum wage not yet for everyone: On the compensation of eligible workers before and after the minimum wage reform from the perspective of employees

open access: green, 2017
Patrick Burauel   +6 more
openalex   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

Academic General and Subspecialty Pediatric Promotion Timelines and Lifetime Earnings.

open access: yesJAMA Netw Open
Ehsan L   +5 more
europepmc   +1 more source

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