Results 41 to 50 of about 107,032 (312)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2008 Küreselleşen dünyada işletmeler aşırırekabet baskısıaltında faaliyetlerine devam etmektedir. İşletmeler için motivasyonu ve işletmeye bağlılığıyüksek çalışan profiline sahip olmak, rekabet avantajısağlayabilme açısından büyük önem taşımaktadır.
Nusret Göksu, Bülent Öz
doaj
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Model complex of forecasting of interdependent development of migration processes and region labour market [PDF]
Экономика региона, 2013 The essential problems of current international labor migration raising the need to forecast interdependent labor market and migration processes in a region for improving the effectiveness of regional migration policy in Russia are considered.
Valery Aleksandrovich Chereshnev +1 more
doaj +1 more source
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
Etnográfica: Revista do Centro em Rede de Investigação em Antropologia, 2010 When a former female manual worker decides to put on gel nails soon after losing the job that had prevented her from making up her hands (as someone in my fieldwork has recently done), it could be tempting to see a shift from a constrained worker ...
Emília Margarida Marques
doaj
Differentiation of the labor sphere under the influence of uneven digitalization
Известия высших учебных заведений. Поволжский регион: Общественные науки, 2023 Background. The current process of digitalization is uneven across the economy, resulting in sectors with intensive use of digital technologies and sectors where these technologies are less widespread. The purpose of the study is to analyze the impact of
Sergey А. Zolotov
doaj +1 more source
Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan +12 more
wiley +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source