Results 51 to 60 of about 296,907 (312)

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial

Arthritis Care &Research, Accepted Article.
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

Changes in Weight, Waist Circumference or Both With Incident Heart Failure in Chinese Middle‐Aged and Older Adults

Journal of Cachexia, Sarcopenia and Muscle
Background Previous studies have acknowledged that higher body weight and waist circumference were associated with an increased risk of heart failure. Notably, both body weight and waist circumference can change over time.
Yu Yin, Rui Tang, Xi Wang, Mengyi Zheng, Jingli Qu, Shuohua Chen, Shouling Wu, Yu Yuan   +7 more
doaj   +1 more source

Association between waist circumference and chronic pain: insights from observational study and two-sample Mendelian randomization

Frontiers in Nutrition
BackgroundCurrent research offers limited clarity on the correlation between waist circumference and chronic pain prevalence.ObjectiveThis investigation seeks to elucidate the potential relationship between waist circumference and chronic pain and their ...
Ting Xu, Fan Jin, Yeting Yu, Jie He, Ren Yang, Tian Lv, Zhangjun Yan   +6 more
doaj   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Association between waist circumference and sleep disorder in the elderly: Based on the NHANES 2005-2018.

PLoS ONE
The existing data do not consistently support the link between elderly adults' waist circumferences and sleep disorders. This study aimed to evaluate whether waist circumference was connected with sleep disorder in the elderly. This cross-sectional study
Yuting Zhong, Ying Li, Maolin Zhong, Cheng Peng, Hui Zhang, Kejun Tian   +5 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Relationship Between the Head Circumference and Waist Circumference

The International Annals of Medicine, 2017
Summary: The purpose of this study therefore is to investigate the relationship between the head circumference and waist circumference of male and female subjects in Nigeria and also if there exists any significant difference in male and female head circumferences and waist circumferences.
Okoro Oghenerieborue Godswill, Enaohwo Taniyohwo Mamerhi   +1 more
openaire   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Associations in waist circumference.

, 2016
Associations between parental waist circumference-based overweight (related to WHO`s cut-off level) and offspring`s waist circumference z-scores at two time points (1995–97 and 2006–08), with both parents being overweight, only mothers being overweight ...
Marit Næss (3350162), Kirsti Kvaløy (126017), Turid Lingaas Holmen (36707), Mette Langaas (440173), Johan Håkon Bjørngaard (461843)   +4 more
core   +1 more source

Chronotype and Peripheral Clock Genes: Association With Frailty and Insomnia in Mexican Older Adults

AGING MEDICINE, EarlyView.
Chronotype, insomnia, frailty, and peripheral clock gene expression were evaluated in community‐dwelling older adults. Extreme morning chronotype was associated with lower odds of insomnia, whereas women showed higher odds of insomnia. Pre‐frail and frail participants exhibited lower peripheral clock gene expression patterns than robust individuals ...
Citlally E. Ortiz‐Vázquez, Paola Garcia‐delaTorre, Sergio Sánchez‐García, Lorena Aguilar‐Arnal, Lucía Mendoza‐Viveros   +4 more
wiley   +1 more source