Results 71 to 80 of about 1,261,896 (297)
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
A Fast-Slow Analysis of the Dynamics of REM Sleep
, 2012 Waking and sleep states are regulated by the coordinated activity of a number of neuronal population in the brainstem and hypothalamus whose synaptic interactions compose a sleep-wake regulatory network.
Booth, Victoria, Diniz Behn, Cecilia G.
core +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer +11 more
wiley +1 more source
Calculating animal performance from limited liveweight measurements of the population [PDF]
, 2003 We consider the problem of estimating the distribution of carcass weights in a flock of animals from estimates made on a truncated sample. This arises when a farmer chooses the heaviest lambs for slaughter and then measurements are made by the meat ...
Pleasants, A.B., Wake, G.C.
core
Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke +5 more
wiley +1 more source
The New Hampshire Greenhouse Gas Emissions Reduction Fund: Year 3 (July 2011-June 2012) Evaluation [PDF]
, 2012 The Greenhouse Gas Emissions Reduction Fund (GHGERF) was created by the New Hampshire legislature in 2008 and has been administered by the New Hampshire Public Utilities Commission (PUC).
Magnusson, Matthew, Wake, Cameron P.
core +1 more source
Kelvin-Mach wake in a two-dimensional Fermi sea [PDF]
, 2018 The dispersion law for plasma oscillations in a two-dimensional electron gas in the hydrodynamic approximation interpolates between $\Omega \propto \sqrt{q}$ and $\Omega \propto q$ dependences as the wave vector $q$ increases.
Kolomeisky, Eugene B. +1 more
core +3 more sources
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
On Blockage Effects for a Tidal Turbine in Free Surface Proximity
Energies, 2019 Experiments with a three-bladed, constant chord tidal turbine were undertaken to understand the influence of free surface proximity on blockage effects and near-wake flow field.
Nitin Kolekar +2 more
doaj +1 more source