Results 101 to 110 of about 90,617 (227)

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Differential effects of ketamine enantiomers on EEG parameters including the gamma‐delta shift phenomenon

British Journal of Pharmacology, EarlyView.
Background and Purpose Ketamine consists of two enantiomers, (R)‐ketamine and (S)‐ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)‐enantiomer has been approved for the treatment of major depressive disorder, whereas recent clinical studies have failed to demonstrate an antidepressant effect for (R)‐ketamine.
Szabolcs Koncz, Dóra Pothorszki, Noémi Papp, Donát Pál, György Bagdy   +4 more
wiley   +1 more source

Non‐epileptic paroxysmal events in Rett syndrome: A systematic review of case‐based and observational evidence

Developmental Medicine &Child Neurology, EarlyView.
This systematic review identifies and categorizes the spectrum of non‐epileptic paroxysmal events in Rett syndrome. Respiratory disturbances, behavioural episodes, and motor events were the most commonly reported. Improving clinician awareness and diagnostic clarity is key to avoiding unnecessary treatment and enhancing quality of life for individuals ...
Natasha Bhatti, Daniel E. Lumsden
wiley   +1 more source

Early neurodevelopmental outcome in newborns with mild hypoxic‐ischaemic encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Aim To describe the natural history of newborn children with mild hypoxic‐ischaemic encephalopathy in the first year of life. Method This was a multicentre, prospective observational study involving five neonatal intensive care units in an Italian region using both structured clinical and neurophysiological assessments according to the Italian Society ...
Domenico M. Romeo, Chiara Arpaia, Angelo Di Malta, Elisa Pede, Grazia Maria Cicala, Daniela Ricci, Francesca Serrao, Eugenio Mercuri, Claudia Brogna, Mild Encephalopathy Regional Network*, Giovanni Vento, Chiara Cafforio, Eleonora Scapillati, Roberta Arena, Francesca Gallini, Vita Augusta, Andrea Guzzetta   +16 more
wiley   +1 more source

Wakefulness.

Hall's journal of health
  +13 more sources

How sleeping minds decide: State-specific reconfigurations of lexical decision-making. [PDF]

PLoS Comput Biol
Xia T, Hu CP, Türker B, Musat EM, Naccache L, Arnulf I, Oudiette D, Hu X.   +7 more
europepmc   +1 more source

Characterising the impact of shift work on diet and glucose variability in healthcare employees living with type 2 diabetes: The Shift‐Diabetes study

Diabetic Medicine, EarlyView.
Abstract Aims To characterise differences in dietary intake, glucose variability, and activity in free‐living healthcare shift workers with type 2 diabetes (T2D) across varying work conditions. Methods Healthcare shift workers with T2D were monitored over 10 days, covering night shifts, day shifts, and rest days.
Rachel Gibson, Maria D'Annibale, Luigi Palla, Felicia Tejo, Barbara McGowan, Celine Vetter, Fabiana Lorencatto, Nick Oliver, Nicola Guess   +8 more
wiley   +1 more source

Wakefulness regulation of memory encoding and retrieval: structure and activity. [PDF]

Natl Sci Rev
Luo YJ, Su WK, Yao W, Jiang H, McHugh TJ, Li YD.   +5 more
europepmc   +1 more source

Felons’ chattels and English living standards in the later fourteenth and fifteenth centuries

The Economic History Review, EarlyView.
Abstract The later fourteenth and fifteenth centuries have long occupied an intriguing and contested place in discussions of England's long‐run economic development. One key issue around which debate has coalesced is the living standards of the population as a whole and of different groups within it. We contribute to this debate by bringing forward new
Chris Briggs, Ben Jervis, Alice Forward, Tomasz Gromelski, Matthew Tompkins   +4 more
wiley   +1 more source

The Bed Nucleus of the Stria Terminalis-Deep Mesencephalic Nucleus Circuit Linking Emotion and Wakefulness. [PDF]

J Neurosci
Zhang Z, Cherasse Y, Louis C, Saito YC, Soya S, Hirano A, Sakurai T.   +6 more
europepmc   +1 more source