Results 51 to 60 of about 82,329 (299)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Structural Break Tests Robust to Regression Misspecification

Econometrics, 2018
Structural break tests for regression models are sensitive to model misspecification. We show—analytically and through simulations—that the sup Wald test for breaks in the conditional mean and variance of a time series process exhibits severe
Alaa Abi Morshed, Elena Andreou, Otilia Boldea   +2 more
doaj   +1 more source

Wald tests for main effects and interactions for binomial GLMM fit to the number of unavailable snails in control and experimental trials.

, 2023
Wald tests for main effects and interactions for binomial GLMM fit to the number of unavailable snails in control and experimental trials.
Salohy Ravelotafita (16979368), Chelsea L. Wood (8034611), Peter Rabinowitz (845362), Julian D. Olden (8730243), Luciano Andriamaro (3588095), Sara M. Faiad (16979350), Julia Patricia Gordon Jones (16979362), Tsilavina Ravelomanana (16979365), Maurice Goodman (6833306), Jeanne Rasamy (6309830), Ranaivosolo Ravo (16979371), Pascaline Ravoniarimbinina (599775), Ranja Andriantsoa (6309818), Maureen A. Williams (16979353), Susanne Sokolow (16979356), Giulio A. De Leo (7871858), Kaitlyn Mitchell (16979359)   +16 more
core   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Wald tests for main effects and interactions for binomial GLMM fit to the number of dead snails in control and experimental trials.

, 2023
Wald tests for main effects and interactions for binomial GLMM fit to the number of dead snails in control and experimental trials.
Salohy Ravelotafita (16979368), Chelsea L. Wood (8034611), Peter Rabinowitz (845362), Julian D. Olden (8730243), Luciano Andriamaro (3588095), Sara M. Faiad (16979350), Julia Patricia Gordon Jones (16979362), Tsilavina Ravelomanana (16979365), Maurice Goodman (6833306), Jeanne Rasamy (6309830), Ranaivosolo Ravo (16979371), Pascaline Ravoniarimbinina (599775), Ranja Andriantsoa (6309818), Maureen A. Williams (16979353), Susanne Sokolow (16979356), Giulio A. De Leo (7871858), Kaitlyn Mitchell (16979359)   +16 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Adaptive Detection of Range-distributed Targets in Weighted Generalized Inverse Gaussian Clutter

Leida xuebao
In this paper, we investigate the adaptive detection of range-distributed targets in compound-Gaussian clutter, where the texture component follows a Weighted Generalized Inverse Gaussian (WGIG) distribution.
Zhenyu XU, Weijian LIU, Xiaolong CHEN, Hui CHEN, Qinglei DU, Binbin LI, Bilei ZHOU   +6 more
doaj   +1 more source

Influence analysis of robust Wald-type tests

Journal of Multivariate Analysis, 2016
36 ...
Abhik Ghosh, Abhijit Mandal, Nirian Martín, Leandro Pardo   +3 more
openaire   +3 more sources

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Homogeneity Test of Response Rate Functions in Bilateral Correlated Data under Dallal’s Model

Complexity, 2023
In clinical studies, paired binary metadata are often encountered during collecting information from paired organs or parts. The risk difference, relative risk ratio, and odds ratios of response rates are widely used to measure cured effects for such ...
Hengyi Zhao, Xiaojuan Wang, Jingwen Bian, Shenglong Chen, Zhiming Li   +4 more
doaj   +1 more source