Results 121 to 130 of about 2,229,116 (379)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Walking Through Waypoints

, 2018
We initiate the study of a fundamental combinatorial problem: Given a capacitated graph $G=(V,E)$, find a shortest walk ("route") from a source $s\in V$ to a destination $t\in V$ that includes all vertices specified by a set $\mathscr{W}\subseteq V$: the
Amiri, Saeed Akhoondian, Foerster, Klaus-Tycho, Schmid, Stefan   +2 more
core   +1 more source

Factors influencing walking distance to the preferred public transport stop in selected urban centres of Czechia [PDF]

, 2019
One of the ways of improving the attractiveness of public transport is to bring it closer to its potential users. A long walking distance from a stop is often one of the critical factors limiting its more frequent and extensive use.
Burian, Jaroslav, Fojtík, David, Horák, Jiří, Ivan, Igor, Zajíčková, Lenka   +4 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

Dynamic postural stability changes of the subjects with toe-in gait due to increase in femoral head anteversion angle during walking [PDF]

Advances in Medicine, Psychology, and Public Health
Background: Toe-in gait may be caused by an increase in femoral head anteversion angle. The objective of this study was to assess the impact of toe-in gait on stability during walking.
Mohammad Taghi Karimi, Mahmood Bahramizadeh, Amirhossein Zare, Hanieh Khaliliyan, Alireza Khaghani, Shahla Mohajeri, Majid Ansari, Farhad Ghaffari, Arash Sharafatvaziri   +8 more
doaj   +1 more source

Dynamics of Human Walking

, 2004
The problem of biped locomotion at steady speeds is discussed through a Lagrangian formulation developed for velocity-dependent, body driving forces. Human walking on a level surface is analyzed in terms of the data on the resultant ground-reaction force
G. A. Cavanga, G. A. Cavanga, H. Goldstein, L. D. Landau, P. A. Willems, R. McN. Alexander, S. M. Gatesy   +6 more
core   +2 more sources

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

(Just) a walk with the dog? Animal geographies and negotiating walking spaces

, 2018
In this paper, we present findings from interviews conducted with people who walk with dogs. Drawing on new walking studies and animal geographies as our theoretical framework, we adopt the view that walking is more than just walking; it is often a ...
T. Fletcher, Louise Platt
semanticscholar   +1 more source

Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over

Arthritis Care &Research, EarlyView.
Objective Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged ≥70 years old.
Amanda J. Rickard, Cammie Tran, Hans G. Schneider, Flavia M. Cicuttini, Anita E. Wluka, Ego Seeman, Johannes T. Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain, David P. Q. Clark, Daniel Clayton‐Chubb, Andrew M. Tonkin, Lawrence J. Beilin, Robyn L. Woods, John J. McNeil   +15 more
wiley   +1 more source