Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Crime Networks with Bargaining and Build Frictions [PDF]
How does the timing, targets and types of anti-crime policies affect a network when criminal retailers search sequentially for wholesalers and crime opportunities?
Bryan Engelhardt
core
Border Security: A Comprehensive Review of the United States’ Approach to Southwest Border Policy [PDF]
, 2015 This paper addresses the effect that the presence of a physical border wall on the southern United States-Mexico border has on deterring unauthorized immigration, illegal drug-trafficking, and countering narco-terrorism.
Pacheco, Nicholas M.
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The neocolonial logics underpinning the “war on drugs” in the Philippines
Oñati Socio-Legal SeriesThe “war on drugs” in the Philippines has claimed thousands of people lives and has resulted in the detention of hundreds of thousands of drug users. Legal professionals working in criminal courts have adopted a “punitive paternalism” when dealing with ...
Pablo Leandro Ciocchini
doaj +1 more source
Different Wars Require Different Strategies: Separating the “War on Drugs” from the “War on Drug [Traffickers]” [PDF]
, 2013 Using the securitization framework to highlight the arguments that facilitated the “War on Drugs”, this paper highlights a separate war against drug traffickers.
Reyes, Liana Eustacia
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Methadone maintenance treatment is swapping one drug for another, and that's why it works: Towards a treatment-based critique of the war on drugs. [PDF]
Int J Drug Policy, 2020 Frank D.
europepmc +1 more source
The war on illegal drugs in producer and consumer countries: a simple analytical framework [PDF]
, 2008 This paper develops a model of the war against illegal drugs in both producer and consumer countries. The paper studies the trade-off faced by the government of the drug consumer country between prevention policies (aimed at reducing the demand for drugs)
Mejía, Daniel
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source