Results 101 to 110 of about 502,644 (306)

On President Rodrigo Duterte’s “War On Drugs”: Its Impact on Philippine-China Relations [PDF]

open access: yesContemporary Chinese Political Economy and Strategic Relations: An International Journal, 2019
This study looks into the “War on Drugs” of the Duterte Administration and how it impacts on the diplomatic relations between the Philippines and China.
Diosdado B. Lopega
doaj  

The Need for New Approaches to Organised Crime in West Africa [PDF]

open access: yes, 2012
LSE’s Sasha Jesperson argues that international organisations will need to vary their strategy in the war on drugs if they are to gain ground on adaptable narco ...
Jesperson, Sasha
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A “Dubious Distinction”: New Jersey’s Drug-Free School Zones & Disparately Impacted Minority Communities [PDF]

open access: yes, 2014
Richard Nixon fundamentally changed the prison system in America when he launched the “War on Drugs” in 1969, leading to a series of federal laws imposing harsh mandatory sentences on drug offenders.
Overman, Taylor R.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

La reconstruction par association des problèmes publics : retour sur l’invention du blanchiment d’argent

open access: yesCriminologie, 2016
L’objectif du présent article est de revenir sur les conditions d’émergence du problème de l’argent sale dont la prise en charge a contribué à déstabiliser de façon inédite le principe du secret bancaire.
Anthony Amicelle
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ricardo Diaz - Latino/a Mass Incarceration in relation to the “War on Drugs” [PDF]

open access: yes, 2013
Michelle Alexander, in The New Jim Crow, argues that the American legal system is a racial caste system maintained by unequal drug laws, what she terms, “The New Jim Crow” laws.
Diaz, Ricardo
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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