Results 91 to 100 of about 502,644 (306)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Calls for a radical change in West Africa’s drug policy [PDF]

open access: yes, 2014
A new report by the West Africa Commission on Drugs (WACD) has called for a radical rethink on how West African governments tackle the war on drugs.
Jesperson, Sasha
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Do Filipinos Really Hate Duterte’s Leadership? Uncovering Duterte Controversies in the Philippines

open access: yesJournal of Asian Social Science Research
This article investigates whether Filipinos genuinely have negative feelings about President Duterte’s leadership. It examines public opinions through surveys, media discussions, and actions in socio-political groups.
Givheart Dano
doaj   +1 more source

That Look That Makes You Not Really Want to be There: How Neoliberalism and the War on Drugs Compromise Nursing Care of People Who Use Substances

open access: yesWitness, 2019
Research conducted in 2016 explored the health care experiences of people who use illicit opioids in small Ontario urban and rural communities. Perspectives of participants who used opioids and of nurse participants were interpreted using Friere’s ...
Kathy Hardill
doaj   +1 more source

The War on Illegal Drug Production and Trafficking: An Economic Evaluation of Plan Colombia. [PDF]

open access: yes
This paper provides a thorough economic evaluation of the anti-drug policies implemented in Colombia between 2000 and 2006 under the so-called Plan Colombia.
Daniel Mejía, Pascual Restrepo
core  

Do Black and White Americans Hold Different Views on Marijuana Legalization? Analyzing the Impact of “The War on Drugs” on Racialized Perceptions of Legalizing Marijuana [PDF]

open access: yes, 2018
This study examines whether Black and White Americans develop their views regarding the legalization of marijuana based on different life experiences and, specifically, their involvement with the criminal justice system and drug laws.
Kaminoff, Benjamin S
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The War...on drugs.

open access: yesRevue LISA, 2020
David Connolly
doaj   +1 more source

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