Results 201 to 210 of about 13,460,861 (391)

A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer

Cell Reports
Summary: Pancreatic ductal adenocarcinoma (PDAC) features substantial matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect.
Jia-Hao Zheng, Yu-Heng Zhu, Jian Yang, Pei-Xuan Ji, Rui-Kang Zhao, Zong-Hao Duan, Hong-Fei Yao, Qin-Yuan Jia, Yi-Fan Yin, Li-Peng Hu, Qing Li, Shu-Heng Jiang, Yan-Miao Huo, Wei Liu, Yong-Wei Sun, De-Jun Liu   +15 more
doaj   +1 more source

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]

, 2011
Alexei Vázquez
openalex   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates

, 2004
Tetsufumi Koike, Naoko Kimura, Keiko Miyazaki, Tomonori Yabuta, Kensuke Kumamoto, Seiichi Takenoshita, Jian Chen, Masanobu Kobayashi, Masuo Hosokawa, Akiyoshi Taniguchi, Tetsuhito Kojima, Nobuhiro Ishida, Masao Kawakita, Harumi Yamamoto, Hiromu Takematsu, Akemi Suzuki, Yasunori Kozutsumi, Reiji Kanangi   +17 more
openalex   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
wiley   +1 more source

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo [PDF]

, 2012
Brandon Faubert, Gino Boily, Said Izreig, Takla Griss, Bożena Samborska, Zhifeng Dong, Fanny Dupuy, Christopher B. Chambers, Benjamin J. Fuerth, Benoı̂t Viollet, Orval Mamer, Daina Avizonis, Ralph J. DeBerardinis, Peter M. Siegel, Russell G. Jones   +14 more
openalex   +1 more source

Medium‐Entropy Engineering Enhances Na⁺/Electron Transport in Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs Cathode for Sodium‐Ion Batteries

Advanced Science, EarlyView.
This study proposes a medium‐entropy strategy to enhance sodium vanadium fluorophosphate cathodes. The designed Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs composite enhances structural stability and charge transport. Entropy‐induced distortion and carbon nanotubes (CNTs) synergistically improve Na⁺/electron kinetics. In situ XRD reveals a reversible dual‐
Ju Yang, Najun Liu, Guanglu Jiang, Huili Peng, Kan Mi, Nana Wang, Zhongchao Bai, Xiaolei Jiang   +7 more
wiley   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Genome‐wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target [PDF]

, 2012
Marco Gerlinger, Cláudio R. Santos, Bradley Spencer‐Dene, Pierre Martinez, David Endesfelder, Rebecca A. Burrell, Marcus Vetter, Ming Jiang, Rebecca E. Saunders, Gavin Kelly, Karl Dykema, Nathalie Rioux‐Leclercq, Gordon Stamp, Jean Jacques Patard, James Larkin, Michael Howell, Charles Swanton   +16 more
openalex   +1 more source

CuCo‐Layered Double Hydroxide Nanosheets Grown on Hierarchical Carbonized Wood as Bifunctional Electrode for Supercapacitor and Hydrogen Evolution Reaction

Advanced Science, EarlyView.
The N/P co‐doped carbonized wood (NPCW) with open channels is used as the carrier, and in situ uniformly grown copper nanoparticles (Cu NPs) as nucleation centers to induce the vertical growth of CuCo‐LDH nanosheets along the substrate, forming a “carbon‐metal‐LDH” tertiary conductive network, which realizes the synergistic enhancement of high ...
Hewei Hou, Guiqing Lei, Huashuang Huo, Yuanyuan Yu, Zhenzhen Tang, Chengrong Qin, Douyong Min   +6 more
wiley   +1 more source